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<p>Approximately, 1.2 million deaths occur each year from chronic kidney disease worldwide. The incidence is increasing and current treatments have limited efficacy. Many patients with kidney disease inevitably end up with kidney replacement therapy. mRNA has revolutionized the world of molecular therapy and spotlighted the attention of the medical community on its potential clinical application. Currently, mRNA-based therapies have started to emerge in the kidney field. In this review, we describe recent advances in renal mRNA-based therapies and discuss future possibilities for using mRNAs to treat kidney diseases.</p>

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mRNA-based therapies: current progress and future prospects for treating kidney disease

  • 期刊论文

  • 发表日期：

    2025年12月10日

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  • Yiyun Song,
  • Hua Su

摘要

Approximately, 1.2 million deaths occur each year from chronic kidney disease worldwide. The incidence is increasing and current treatments have limited efficacy. Many patients with kidney disease inevitably end up with kidney replacement therapy. mRNA has revolutionized the world of molecular therapy and spotlighted the attention of the medical community on its potential clinical application. Currently, mRNA-based therapies have started to emerge in the kidney field. In this review, we describe recent advances in renal mRNA-based therapies and discuss future possibilities for using mRNAs to treat kidney diseases.