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Background <p>The risk factors for the recurrence of idiopathic nephrotic syndrome (INS) remain unknown. Previous studies have suggested a potential link between matrix metalloproteinase-9 (MMP-9) and urinary protein levels in INS. Therefore, we aimed to investigate the association between serum MMP-9 levels and the risk of subsequent recurrence in patients with INS.</p> Methods <p>This retrospective study included 29 patients with biopsy-proven INS from 1998 to 2016. Baseline serum MMP-9 levels during the nephrotic phase were measured using an enzyme-linked immunosorbent assay. Subsequent recurrence was defined as a change in urinary protein levels from remission to more than 2 + on a dipstick test or more than 1&#xa0;g/g creatinine.</p> Results <p>The median age was 42&#xa0;years (interquartile range: 26.0, 70.0), and 18 patients were males. Over a median follow-up period of 130&#xa0;days, 12 patients (41.4%) experienced recurrences. Patients who experienced recurrence were younger and had higher estimated glomerular filtration rates and baseline serum MMP-9 levels during the nephrotic phase than those who did not. Higher baseline serum MMP-9 levels during the nephrotic phase were associated with a higher risk of subsequent recurrence (hazard ratio: 5.687, 95% confidence interval: 1.179–27.44).</p> Conclusion <p>Baseline serum MMP-9 levels during the nephrotic phase were associated with subsequent recurrence in patients with INS, indicating its potential as a predictive marker for future recurrence in patients with INS.</p>

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Serum matrix metalloproteinase-9 as a predictor of recurrence in idiopathic nephrotic syndrome

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Masahiko Ochi,
  • Akinori Hara,
  • Shiori Nakagawa,
  • Megumi Oshima,
  • Shinji Kitajima,
  • Tadashi Toyama,
  • Norihiko Sakai,
  • Miho Shimizu,
  • Yasunori Iwata,
  • Takashi Wada

摘要

Background

The risk factors for the recurrence of idiopathic nephrotic syndrome (INS) remain unknown. Previous studies have suggested a potential link between matrix metalloproteinase-9 (MMP-9) and urinary protein levels in INS. Therefore, we aimed to investigate the association between serum MMP-9 levels and the risk of subsequent recurrence in patients with INS.

Methods

This retrospective study included 29 patients with biopsy-proven INS from 1998 to 2016. Baseline serum MMP-9 levels during the nephrotic phase were measured using an enzyme-linked immunosorbent assay. Subsequent recurrence was defined as a change in urinary protein levels from remission to more than 2 + on a dipstick test or more than 1 g/g creatinine.

Results

The median age was 42 years (interquartile range: 26.0, 70.0), and 18 patients were males. Over a median follow-up period of 130 days, 12 patients (41.4%) experienced recurrences. Patients who experienced recurrence were younger and had higher estimated glomerular filtration rates and baseline serum MMP-9 levels during the nephrotic phase than those who did not. Higher baseline serum MMP-9 levels during the nephrotic phase were associated with a higher risk of subsequent recurrence (hazard ratio: 5.687, 95% confidence interval: 1.179–27.44).

Conclusion

Baseline serum MMP-9 levels during the nephrotic phase were associated with subsequent recurrence in patients with INS, indicating its potential as a predictive marker for future recurrence in patients with INS.