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Background <p>Colorectal diseases encompass both malignant and benign conditions with significant public health implications. Whilecolorectal cancer (CRC) mortality has been well characterized, population-level mortality trends for benign colorectal conditionsremain poorly defined.</p> Methods <p>This retrospective cohort study analyzed mortality data for U.S. decedents aged ≥15 years from 1999–2020 using the CDCWONDER database. Underlying causes of death were categorized as CRC, inflammatory bowel disease (IBD), or benign colorectalconditions. Crude death rates (CDRs) per million were calculated, and temporal trends were evaluated using Joinpoint regression toestimate annual percent change (APC).</p> Results <p>Of 56,014,102 total deaths, 1,560,448 (2.7%) were due to colorectal pathologies. CRC accounted for most deaths (CDR216.2), followed by benign colorectal conditions (68.5) and IBD (3.8) (p0.001). Among benign causes, Clostridioides difficileenterocolitis (CDR 21.6) was the leading contributor, followed by diverticular disease (12.4) and acute vascular intestinal disorders(9.0). CRC mortality declined significantly (AAPC –1.44%, p0.05), whereas benign colorectal and IBD mortality remained stable.</p> Conclusions <p>Mortality from benign colorectal conditions has persisted over two decades despite major declines in CRC mortality,highlighting unmet needs in research and prevention. Future public health efforts should extend beyond malignancy to addresspreventable deaths from benign colorectal disease.</p>

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Mortality trends from colorectal pathologies in the United States (1999–2020): a retrospective cohort study using CDC WONDER

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月28日

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  • J. L. Rogers,
  • D. Ali,
  • A. Khan

摘要

Background

Colorectal diseases encompass both malignant and benign conditions with significant public health implications. Whilecolorectal cancer (CRC) mortality has been well characterized, population-level mortality trends for benign colorectal conditionsremain poorly defined.

Methods

This retrospective cohort study analyzed mortality data for U.S. decedents aged ≥15 years from 1999–2020 using the CDCWONDER database. Underlying causes of death were categorized as CRC, inflammatory bowel disease (IBD), or benign colorectalconditions. Crude death rates (CDRs) per million were calculated, and temporal trends were evaluated using Joinpoint regression toestimate annual percent change (APC).

Results

Of 56,014,102 total deaths, 1,560,448 (2.7%) were due to colorectal pathologies. CRC accounted for most deaths (CDR216.2), followed by benign colorectal conditions (68.5) and IBD (3.8) (p0.001). Among benign causes, Clostridioides difficileenterocolitis (CDR 21.6) was the leading contributor, followed by diverticular disease (12.4) and acute vascular intestinal disorders(9.0). CRC mortality declined significantly (AAPC –1.44%, p0.05), whereas benign colorectal and IBD mortality remained stable.

Conclusions

Mortality from benign colorectal conditions has persisted over two decades despite major declines in CRC mortality,highlighting unmet needs in research and prevention. Future public health efforts should extend beyond malignancy to addresspreventable deaths from benign colorectal disease.