Scholarlink

Background <p>Low anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.</p> Methods <p>Studies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).</p> Results <p>Of 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = − 10.98; 95% confidence interval (CI) − 13.18, − 8.79], physical functioning (WMD = − 5.96; 95%&#xa0;CI − 7.40, − 4.52), role functioning (WMD = − 10.59; 95%&#xa0;CI − 12.54, − 8.63), emotional functioning (WMD = − 11.09; 95%&#xa0;CI − 14.34, 7.84), cognitive functioning (WMD = − 9.27; 95%&#xa0;CI − 12.22, − 6.32), and social functioning (WMD = − 15.73; 95%&#xa0;CI − 18.82, − 12.63) and higher scores of symptoms compared to patients with minor/no LARS.</p> Conclusions <p>The study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS.</p> Registration <p>PROSPERO, CRD42023479657.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月10日

查看全文
  • S. Shojaei-Zarghani,
  • K. Gorgi,
  • A. Bananzadeh,
  • A. R. Safarpour,
  • S. V. Hosseini

摘要

Background

Low anterior resection syndrome (LARS) is a term that encompasses multidimensional bowel dysfunction that typically occurs following resections of rectum and distal parts of the colon. We aimed to systematically assess the available literature on the effects of bowel dysfunction after colorectal cancer (CRC) surgeries on health-related quality of life (HRQOL) and conduct a meta-analysis.

Methods

Studies were included if they assessed patients who had undergone sphincter-preservation surgeries for CRC. Studies were eligible if they assessed bowel dysfunction using the LARS score and HRQOL using the European Organization for Research and Treatment Core Quality-of-Life Questionnaire (EORTC QLQ-C30).

Results

Of 1410 reports, 28 studies were included. According to the analyses, patients with major LARS had lower global health status [weighted mean differences (WMD) = − 10.98; 95% confidence interval (CI) − 13.18, − 8.79], physical functioning (WMD = − 5.96; 95% CI − 7.40, − 4.52), role functioning (WMD = − 10.59; 95% CI − 12.54, − 8.63), emotional functioning (WMD = − 11.09; 95% CI − 14.34, 7.84), cognitive functioning (WMD = − 9.27; 95% CI − 12.22, − 6.32), and social functioning (WMD = − 15.73; 95% CI − 18.82, − 12.63) and higher scores of symptoms compared to patients with minor/no LARS.

Conclusions

The study findings suggest that patients with major LARS experience worse HRQOL compared to those with minor/no LARS.

Registration

PROSPERO, CRD42023479657.