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Background <p><i>In&#xa0;vivo</i>&#xa0;residual arterial pedicle length (RAPL)&#xa0;has been proposed&#xa0;as a quality&#xa0;indicator&#xa0;for&#xa0;central vascular ligation&#xa0;(CVL&#xa0;[i.e.,&#xa0;RAPL ≤ 10&#xa0;mm])&#xa0;in&#xa0;colorectal cancer (CRC) surgery. However, its&#xa0;survival&#xa0;association&#xa0;in&#xa0;non-routine CVL practice requires clarification.&#xa0;This study aimed to assess&#xa0;the feasibility and reproducibility of measuring&#xa0;RAPL alongside&#xa0;its oncological associations in non-routine&#xa0;CVL&#xa0;surgery.</p> Methods <p>A prospective cohort study at&#xa0;Concord Hospital&#xa0;was conducted on&#xa0;anterior resection (AR) or right hemicolectomy (RH) patients with stage I to III&#xa0;CRC&#xa0;(1995–2019). Using surveillance&#xa0;computed tomography (CT), RAPL of the inferior mesenteric artery (IMA) or ileo-colic artery (ICA) pedicle was&#xa0;measured&#xa0;independently by&#xa0;two&#xa0;observers.&#xa0;The intra-class correlation coefficient assessed&#xa0;the&#xa0;reproducibility&#xa0;of the measurements.&#xa0;Kaplan-Meier and univariate Cox regression analyses&#xa0;estimated overall survival (OS)&#xa0;and&#xa0;disease-free survival (DFS),&#xa0;while&#xa0;univariate and multivariate linear&#xa0;regression models tested correlations between RAPL and clinicopathological features.</p> Results <p>A total of 1425 patients underwent a CRC operation. Post-operative CTs&#xa0;were&#xa0;reviewed&#xa0;in 424 patients,&#xa0;with&#xa0;422 (mean age 69.0&#xa0;years [SD 12.3];&#xa0;54.0% males)&#xa0;RAPLs measured.&#xa0;The majority studied&#xa0;underwent an AR (59.2%).&#xa0;Excellent inter-rater reliability was noted in AR (ICC = 0.97;&#xa0;<i>P</i> &lt; 0.001) and RH (ICC = 0.89;&#xa0;<i>P</i> &lt; 0.001) patients. No association was observed between RAPL and OS or DFS in either group. Also, RAPL lacked association with&#xa0;nodal harvest&#xa0;in&#xa0;either&#xa0;AR (<i>P</i> = 0.54)&#xa0;or RH (<i>P</i> = 0.16) patients.</p> Conclusion <p>The value of RAPL as a quality marker of CRC surgery in non-routine CVL practice has not been confirmed. Furthermore, its lack of association with nodal harvest emphasizes the importance and the need for comprehensive pathology examination of the specimen following resection of CRC.</p>

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Is computed tomography assessment of residual arterial pedicle length following colorectal cancer surgery a useful marker of surgical quality?

  • 期刊论文

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  • 发表日期：

    2025年4月12日

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  • K. Naidu,
  • P. Chapuis,
  • J. Yang,
  • S. Koneru,
  • C. Chan,
  • M. Rickard,
  • K.-S. Ng

摘要

Background

In vivo residual arterial pedicle length (RAPL) has been proposed as a quality indicator for central vascular ligation (CVL [i.e., RAPL ≤ 10 mm]) in colorectal cancer (CRC) surgery. However, its survival association in non-routine CVL practice requires clarification. This study aimed to assess the feasibility and reproducibility of measuring RAPL alongside its oncological associations in non-routine CVL surgery.

Methods

A prospective cohort study at Concord Hospital was conducted on anterior resection (AR) or right hemicolectomy (RH) patients with stage I to III CRC (1995–2019). Using surveillance computed tomography (CT), RAPL of the inferior mesenteric artery (IMA) or ileo-colic artery (ICA) pedicle was measured independently by two observers. The intra-class correlation coefficient assessed the reproducibility of the measurements. Kaplan-Meier and univariate Cox regression analyses estimated overall survival (OS) and disease-free survival (DFS), while univariate and multivariate linear regression models tested correlations between RAPL and clinicopathological features.

Results

A total of 1425 patients underwent a CRC operation. Post-operative CTs were reviewed in 424 patients, with 422 (mean age 69.0 years [SD 12.3]; 54.0% males) RAPLs measured. The majority studied underwent an AR (59.2%). Excellent inter-rater reliability was noted in AR (ICC = 0.97; P < 0.001) and RH (ICC = 0.89; P < 0.001) patients. No association was observed between RAPL and OS or DFS in either group. Also, RAPL lacked association with nodal harvest in either AR (P = 0.54) or RH (P = 0.16) patients.

Conclusion

The value of RAPL as a quality marker of CRC surgery in non-routine CVL practice has not been confirmed. Furthermore, its lack of association with nodal harvest emphasizes the importance and the need for comprehensive pathology examination of the specimen following resection of CRC.