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Background <p>Understanding the relationship between age and prognosis of female lymph node-metastatic gastric cancer (FLMGC) remains limited. This study aimed to elucidate the prognostic impact of age on FLMGC.</p> Methods <p>This population-based retrospective analysis used data from the SEER database. After applying the exclusion criteria, a final cohort of 1,172 FLMGC cases was included. The patients were categorized by age into five groups: ≤ 50&#xa0;years (n = 144), 51–60&#xa0;years (n = 192), 61–70&#xa0;years (n = 291), 71–80&#xa0;years (n = 325), and ≥ 81&#xa0;years (n = 220). Cancer-specific survival (CSS) was selected as the outcome in this study.</p> Results <p>Significant factors for CSS identified in multivariate analysis included age, tumor differentiation, AJCC T and N stages, systemic therapy, number of positive lymph nodes, and total number of retrieved lymph nodes. Age had a nonlinear effect on CSS (P for nonlinearity &lt; 0.001), with the lowest risk occurring in the 55–60&#xa0;year age group.</p> Conclusions <p>This SEER-based study revealed a nonlinear relationship between age and FLMGC prognosis, with the lowest risk occurring in the 55–60-year age group.</p>

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Age-related prognostic trends in surgically resected female lymph node-metastatic gastric cancer: insights from SEER

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Bozhi Hu,
  • Yinli Zhang,
  • Yingjiang Ye,
  • Zhidong Gao,
  • Chao Wang

摘要

Background

Understanding the relationship between age and prognosis of female lymph node-metastatic gastric cancer (FLMGC) remains limited. This study aimed to elucidate the prognostic impact of age on FLMGC.

Methods

This population-based retrospective analysis used data from the SEER database. After applying the exclusion criteria, a final cohort of 1,172 FLMGC cases was included. The patients were categorized by age into five groups: ≤ 50 years (n = 144), 51–60 years (n = 192), 61–70 years (n = 291), 71–80 years (n = 325), and ≥ 81 years (n = 220). Cancer-specific survival (CSS) was selected as the outcome in this study.

Results

Significant factors for CSS identified in multivariate analysis included age, tumor differentiation, AJCC T and N stages, systemic therapy, number of positive lymph nodes, and total number of retrieved lymph nodes. Age had a nonlinear effect on CSS (P for nonlinearity < 0.001), with the lowest risk occurring in the 55–60 year age group.

Conclusions

This SEER-based study revealed a nonlinear relationship between age and FLMGC prognosis, with the lowest risk occurring in the 55–60-year age group.