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Background <p>Roles of induction chemotherapy (ICT) and chemoradiotherapy (CRT) for laryngeal preservation in patients with locally advanced laryngeal cancer (LC) remain unclear.</p> Patients and methods <p>We enrolled 834 patients with T3N0-2M0 and T4aN0-2M0 LC registered in the Head and Neck Cancer Registry of Japan between 2011 and 2015. Oncological outcomes of total laryngectomy (TL), CRT, and ICT were evaluated. Propensity score-matching analyses (PSMA) were performed between TL and CRT, excluding ICT.</p> Results <p>No significant differences were observed in overall survival (OS) and disease-specific survival (DSS) among patients treated by TL, CRT, and ICT followed by TL or CRT, and among patients treated by TL and CRT in PSMA. Of note, no significant difference was observed in LCR and LRFS between TL and ICT groups.</p> Conclusions <p>ICT and CRT did not yield survival benefits but might contribute to laryngeal preservation without compromising survival in patients with T3-4aN0-2M0.</p>

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Survival outcomes of the patients with advanced laryngeal squamous cell carcinoma treated with chemoradiotherapy and total laryngectomy based on reports of head and neck cancer registry of Japan

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Yuta Yamamura,
  • Yuto Horichi,
  • Tatsuya Furukawa,
  • Hirotaka Shinomiya,
  • Megumi Kitayama,
  • Daisuke Kawakita,
  • Takeshi Kodaira,
  • Munenaga Nakamizo,
  • Seiichi Yoshimoto,
  • Ken-ichi Nibu

摘要

Background

Roles of induction chemotherapy (ICT) and chemoradiotherapy (CRT) for laryngeal preservation in patients with locally advanced laryngeal cancer (LC) remain unclear.

Patients and methods

We enrolled 834 patients with T3N0-2M0 and T4aN0-2M0 LC registered in the Head and Neck Cancer Registry of Japan between 2011 and 2015. Oncological outcomes of total laryngectomy (TL), CRT, and ICT were evaluated. Propensity score-matching analyses (PSMA) were performed between TL and CRT, excluding ICT.

Results

No significant differences were observed in overall survival (OS) and disease-specific survival (DSS) among patients treated by TL, CRT, and ICT followed by TL or CRT, and among patients treated by TL and CRT in PSMA. Of note, no significant difference was observed in LCR and LRFS between TL and ICT groups.

Conclusions

ICT and CRT did not yield survival benefits but might contribute to laryngeal preservation without compromising survival in patients with T3-4aN0-2M0.