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Background <p>Esophageal squamous cell carcinoma (ESCC) presents significant treatment challenges, with chemoradiotherapy (CRT) leading to local recurrence in 30–40% of cases. Limitations of traditional salvage therapies have driven interest in photodynamic therapy with talaporfin sodium (TS–PDT), a minimally invasive treatment with reduced phototoxicity, which has been increasingly utilized since its approval in Japan.</p> Methods <p>This retrospective study at the Nagoya City University Hospital (May 2016–December 2023) assessed the efficacy of TS–PDT for esophageal cancer after CRT or radiotherapy in 29 patients who met specific inclusion criteria. The evaluated outcomes included adverse events, local complete response (L-CR), progression-free survival (PFS), and overall survival (OS).</p> Results <p>Among the patients (23 men and 6 women; median age, 72 years), TS–PDT achieved an L-CR rate of 81.5% per patient and 87.8% per lesion, with a higher success rate against T1b lesions. The median local PFS was 44.1 months, and OS had not yet been reached, with a 1-year survival rate of 91.9%. The adverse events included esophageal strictures and perforations.</p> Conclusion <p>TS–PDT is a potentially effective salvage treatment for ESCC, offering efficient local control and favorable survival outcomes. Despite some adverse events, its reduced phototoxicity and versatility make it a viable option, particularly for elderly patients. Further multicenter trials are warranted to validate its role in esophageal cancer management.</p>

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Efficacy and safety of talaporfin sodium photodynamic therapy as a salvage treatment for locally recurrent esophageal squamous cell carcinoma

  • 期刊论文

  • 发表日期：

    2025年9月2日

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  • Mamoru Tanaka,
  • Makiko Sasaki,
  • Hirotada Nishie,
  • Yuki Kojima,
  • Yasunari Sasaki,
  • Taketo Suzuki,
  • Shigeki Fukusada,
  • Naomi Sugimura,
  • Keiji Ozeki,
  • Takaya Shimura,
  • Eiji Kubota,
  • Hiromi Kataoka

摘要

Background

Esophageal squamous cell carcinoma (ESCC) presents significant treatment challenges, with chemoradiotherapy (CRT) leading to local recurrence in 30–40% of cases. Limitations of traditional salvage therapies have driven interest in photodynamic therapy with talaporfin sodium (TS–PDT), a minimally invasive treatment with reduced phototoxicity, which has been increasingly utilized since its approval in Japan.

Methods

This retrospective study at the Nagoya City University Hospital (May 2016–December 2023) assessed the efficacy of TS–PDT for esophageal cancer after CRT or radiotherapy in 29 patients who met specific inclusion criteria. The evaluated outcomes included adverse events, local complete response (L-CR), progression-free survival (PFS), and overall survival (OS).

Results

Among the patients (23 men and 6 women; median age, 72 years), TS–PDT achieved an L-CR rate of 81.5% per patient and 87.8% per lesion, with a higher success rate against T1b lesions. The median local PFS was 44.1 months, and OS had not yet been reached, with a 1-year survival rate of 91.9%. The adverse events included esophageal strictures and perforations.

Conclusion

TS–PDT is a potentially effective salvage treatment for ESCC, offering efficient local control and favorable survival outcomes. Despite some adverse events, its reduced phototoxicity and versatility make it a viable option, particularly for elderly patients. Further multicenter trials are warranted to validate its role in esophageal cancer management.