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Background <p>Head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) sometimes synchronously exist. In this study, we aim to investigate survival outcome and late adverse events (AEs) in patients with locally advanced synchronous ESCC and HNSCC (LA-SEHNC).</p> Methods <p>We retrospectively analyzed consecutive patients with LA-SEHNC who underwent curative-intent surgery or chemoradiotherapy (CRT) for HNSCC and ESCC between 2007 and 2024. Patients were classified into 3 groups: group A, surgery for both HNSCC and ESCC; group B, CRT for both HNSCC and ESCC; group C, CRT for either HNSCC or ESCC.</p> Results <p>Forty-two patients with LA-SEHNC were identified, consisting of 7 in group A, 28 in B, and 7 in C. There were no differences in overall survival and recurrence-free survival among groups. Late AEs occurred more frequently in group B and C than A, including stenosis (51.9%/57.1% vs 0%; <i>p</i> = 0.04), dysphagia (59.3%/42.9% vs 0% vs.; <i>p</i> = 0.02), and xerostomia (74.1%/57.1% vs 14.3%; <i>p</i> = 0.01). The median duration of feeding tube dependency was significantly longer in group B than A (80&#xa0;days vs 0&#xa0;day; <i>p</i> &lt; 0.01). PS ≥ 1 and irradiation at head and neck region was significantly associated with long-term feeding tube dependency (odds ratio [OR] 9.10, <i>p</i> = 0.005, OR 7.71e + 7, <i>p</i> = 0.024, respectively).</p> Conclusion <p>Although no significant difference in survival was found among patients with LA-SEHNC regardless of treatment modalities, the use of radiotherapy may be associated with increased late AEs.</p>

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Multimodal treatments for patients with locally advanced synchronous esophageal and head and neck cancer

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Satoshi Suzuki,
  • Tomoya Yokota,
  • Akifumi Notsu,
  • Satoshi Hamauchi,
  • Kunihiro Fushiki,
  • Kotoe Oshima,
  • Akihiro Ohba,
  • Takeshi Kawakami,
  • Takahiro Tsushima,
  • Hirofumi Yasui,
  • Kentaro Yamazaki,
  • Yusuke Onozawa,
  • Takashi Mukaigawa,
  • Yasuhiro Tsubosa,
  • Hirofumi Ogawa,
  • Tsuyoshi Onoe

摘要

Background

Head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) sometimes synchronously exist. In this study, we aim to investigate survival outcome and late adverse events (AEs) in patients with locally advanced synchronous ESCC and HNSCC (LA-SEHNC).

Methods

We retrospectively analyzed consecutive patients with LA-SEHNC who underwent curative-intent surgery or chemoradiotherapy (CRT) for HNSCC and ESCC between 2007 and 2024. Patients were classified into 3 groups: group A, surgery for both HNSCC and ESCC; group B, CRT for both HNSCC and ESCC; group C, CRT for either HNSCC or ESCC.

Results

Forty-two patients with LA-SEHNC were identified, consisting of 7 in group A, 28 in B, and 7 in C. There were no differences in overall survival and recurrence-free survival among groups. Late AEs occurred more frequently in group B and C than A, including stenosis (51.9%/57.1% vs 0%; p = 0.04), dysphagia (59.3%/42.9% vs 0% vs.; p = 0.02), and xerostomia (74.1%/57.1% vs 14.3%; p = 0.01). The median duration of feeding tube dependency was significantly longer in group B than A (80 days vs 0 day; p < 0.01). PS ≥ 1 and irradiation at head and neck region was significantly associated with long-term feeding tube dependency (odds ratio [OR] 9.10, p = 0.005, OR 7.71e + 7, p = 0.024, respectively).

Conclusion

Although no significant difference in survival was found among patients with LA-SEHNC regardless of treatment modalities, the use of radiotherapy may be associated with increased late AEs.