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Background <p>As a follow-up study to our prospective phase II trial of concurrent chemoradiotherapy (CCRT) with weekly low-dose carboplatin for cisplatin-ineligible patients with head and neck squamous cell carcinoma (HNSCC), we assessed long-term survival (minimum follow-up of 2-year) and subgroup analysis by age and renal function.</p> Methods <p>A prospective phase II study on CCRT with weekly low-dose carboplatin for cisplatin-ineligible HNSCC in 30 patients who were aged (≥ 75-year-old patients with 40 mL/min estimated glomerular filtration rate [eGFR] or better) or had renal dysfunction (&lt; 75-year-old patients with 30–60 mL/min eGFR) was performed between July 2019 and January 2022 at three tertiary hospitals. Survival outcomes were investigated 2&#xa0;years after this phase 2 trial were investigated. Furthermore, we compared the treatment outcome between ≥ 75 years group and &lt; 75 years group.</p> Results <p>The median follow-up time was 41.5 months. The 2-year recurrence-free survival (RFS) and 2-year overall survival (OS) rates of all patients were 70% and 86.7%, respectively. The 2-year RFS and OS of patients ≥ 75 years old was 92.3% and 100%, respectively, whereas those of patients &lt; 75 years old was 52.9% (p = 0.175) and 76% (p = 0.157), respectively, showing no significant differences between the groups.</p> Conclusion <p>CCRT with weekly low-dose carboplatin in patients with cisplatin-ineligible HNSCC showed favorable survival outcomes irrespective of age and renal function. This study highlights a potentially promising treatment option for cisplatin-ineligible HNSCC patients.</p> Trial registration <p>jRCTs031190028</p>

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Concurrent chemoradiotherapy with weekly low-dose carboplatin for cisplatin-ineligible patients with head and neck squamous cell carcinoma: survival analysis based on 2-year follow-up data

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Yushi Ueki,
  • Yuki Ohno,
  • Shusuke Ohshima,
  • Yusuke Yokoyama,
  • Jo Omata,
  • Takeshi Takahashi,
  • Ryusuke Shodo,
  • Keisuke Yamazaki,
  • Kohei Ohtaki,
  • Kohei Saijo,
  • Ryoko Tanaka,
  • Nao Takahashi,
  • Ryuichi Okabe,
  • Arata Horii

摘要

Background

As a follow-up study to our prospective phase II trial of concurrent chemoradiotherapy (CCRT) with weekly low-dose carboplatin for cisplatin-ineligible patients with head and neck squamous cell carcinoma (HNSCC), we assessed long-term survival (minimum follow-up of 2-year) and subgroup analysis by age and renal function.

Methods

A prospective phase II study on CCRT with weekly low-dose carboplatin for cisplatin-ineligible HNSCC in 30 patients who were aged (≥ 75-year-old patients with 40 mL/min estimated glomerular filtration rate [eGFR] or better) or had renal dysfunction (< 75-year-old patients with 30–60 mL/min eGFR) was performed between July 2019 and January 2022 at three tertiary hospitals. Survival outcomes were investigated 2 years after this phase 2 trial were investigated. Furthermore, we compared the treatment outcome between ≥ 75 years group and < 75 years group.

Results

The median follow-up time was 41.5 months. The 2-year recurrence-free survival (RFS) and 2-year overall survival (OS) rates of all patients were 70% and 86.7%, respectively. The 2-year RFS and OS of patients ≥ 75 years old was 92.3% and 100%, respectively, whereas those of patients < 75 years old was 52.9% (p = 0.175) and 76% (p = 0.157), respectively, showing no significant differences between the groups.

Conclusion

CCRT with weekly low-dose carboplatin in patients with cisplatin-ineligible HNSCC showed favorable survival outcomes irrespective of age and renal function. This study highlights a potentially promising treatment option for cisplatin-ineligible HNSCC patients.

Trial registration

jRCTs031190028