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<p>Data on the use of Woven EndoBridge (WEB) devices in the treatment of narrow-neck intracranial aneurysms (NNA) are limited. We compared the efficacy and safety of single-layer (SL) and single-layer spherical (SLS) WEB devices in treating NNA. We conducted a multicenter retrospective analysis of adult patients with NNA (neck ≤ 4&#xa0;mm and width-to-neck ratio ≥ 2) treated with SL or SLS WEB devices between January 2011 and December 2022. Patients with fusiform or blister aneurysms, adjunctive treatments, or devices other than SL or SLS were excluded. Propensity score matching was used to adjust for confounding variables. Outcomes included procedural complications, angiographic occlusion rates using the Raymond Roy classification, major device compaction, need for retreatment, and functional outcomes assessed by the modified Rankin Scale (mRS). After matching, resulting in 101 patients in each group, baseline characteristics were well-balanced. Thromboembolic complications occurred in 2.0% of the SLS group and 5.9% of the SL group (<i>P</i> = 0.28). Hemorrhagic complications occurred in 1.0% of the SLS group and 6.4% of the SL group (<i>P</i> = 0.062). Adequate occlusion rates (Raymond Roy grades I and II) were similar between groups (96% in SLS vs. 91% in SL; <i>P</i> = 0.20). Major device compaction was significantly less frequent in the SLS group compared to the SL group (0% vs. 7.6%; <i>P</i> = 0.024). The need for retreatment trended to be lower in the SLS group (1.1% vs. 6.6% in SL; <i>P</i> = 0.12). Functional outcomes (mRS 0–1) at last follow-up were comparable (82% in SLS vs. 86% in SL; <i>P</i> = 0.41). In the treatment of narrow-neck intracranial aneurysms, the SLS WEB device was associated with significantly lower rates of major device compaction compared to the SL device. Reduced compaction may lead to a lower need for retreatment. Overall imaging outcomes and safety profiles were similar between the two devices.</p>

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Single-layer spherical (SLS) vs single-layer (SL) Woven EndoBridge (WEB) device in the treatment of narrow-neck intracranial aneurysms: a propensity score-matched analysis

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  • 发表日期：

    2026年3月3日

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  • Hamza Adel Salim,
  • Vivek Yedavalli,
  • Fathi Milhem,
  • Nimer Adeeb,
  • Basel Musmar,
  • Muhammed Amir Essibayi,
  • Motaz Daraghma,
  • Mahmoud Dibas,
  • Nicole M. Cancelliere,
  • Jose Danilo Bengzon Diestro,
  • Oktay Algin,
  • Sherief Ghozy,
  • Sovann V. Lay,
  • Adrien Guenego,
  • Leonardo Renieri,
  • Joseph Carnevale,
  • Guillaume Saliou,
  • Panagiotis Mastorakos,
  • Kareem El Naamani,
  • Eimad Shotar,
  • Markus Möhlenbruch,
  • Michael Kral,
  • Charlotte Chung,
  • Mohamed M. Salem,
  • Ivan Lylyk,
  • Paul M. Foreman,
  • Hamza Shaikh,
  • Vedran Župančić,
  • Muhammad U. Hafeez,
  • Joshua Catapano,
  • Muhammad Waqas,
  • Muhammet Arslan,
  • Onur Ergun,
  • James D. Rabinov,
  • Julian Maingard,
  • Clemens M. Schirmer,
  • Mariangela Piano,
  • Anna L. Kühn,
  • Caterina Michelozzi,
  • Robert M. Starke,
  • Ameer Hassan,
  • Mark Ogilvie,
  • Anh Nguyen,
  • Jesse Jones,
  • Waleed Brinjikji,
  • Marie T. Nawka,
  • Marios Psychogios,
  • Christian Ulfert,
  • Bryan Pukenas,
  • Jan-Karl Burkhardt,
  • Thien Huynh,
  • Juan Carlos Martinez-Gutierrez,
  • Sunil A. Sheth,
  • Diana Slawski,
  • Rabih Tawk,
  • Benjamin Pulli,
  • Boris Lubicz,
  • Pietro Panni,
  • Ajit S. Puri,
  • Guglielmo Pero,
  • Eytan Raz,
  • Christoph J. Griessenauer,
  • Hamed Asadi,
  • Adnan Siddiqui,
  • Elad I. Levy,
  • Neil Haranhalli,
  • David Altschul,
  • Andrew F. Ducruet,
  • Felipe C. Albuquerque,
  • Robert W. Regenhardt,
  • Christopher J. Stapleton,
  • Peter Kan,
  • Vladimir Kalousek,
  • Pedro Lylyk,
  • Srikanth Boddu,
  • Jared Knopman,
  • Stavropoula I. Tjoumakaris,
  • Hugo H. Cuellar-Saenz,
  • Pascal M. Jabbour,
  • Frédéric Clarençon,
  • Nicola Limbucci,
  • Vitor Mendes Pereira,
  • Aman B. Patel,
  • Max Wintermark,
  • Adam A. Dmytriw

摘要

Data on the use of Woven EndoBridge (WEB) devices in the treatment of narrow-neck intracranial aneurysms (NNA) are limited. We compared the efficacy and safety of single-layer (SL) and single-layer spherical (SLS) WEB devices in treating NNA. We conducted a multicenter retrospective analysis of adult patients with NNA (neck ≤ 4 mm and width-to-neck ratio ≥ 2) treated with SL or SLS WEB devices between January 2011 and December 2022. Patients with fusiform or blister aneurysms, adjunctive treatments, or devices other than SL or SLS were excluded. Propensity score matching was used to adjust for confounding variables. Outcomes included procedural complications, angiographic occlusion rates using the Raymond Roy classification, major device compaction, need for retreatment, and functional outcomes assessed by the modified Rankin Scale (mRS). After matching, resulting in 101 patients in each group, baseline characteristics were well-balanced. Thromboembolic complications occurred in 2.0% of the SLS group and 5.9% of the SL group (P = 0.28). Hemorrhagic complications occurred in 1.0% of the SLS group and 6.4% of the SL group (P = 0.062). Adequate occlusion rates (Raymond Roy grades I and II) were similar between groups (96% in SLS vs. 91% in SL; P = 0.20). Major device compaction was significantly less frequent in the SLS group compared to the SL group (0% vs. 7.6%; P = 0.024). The need for retreatment trended to be lower in the SLS group (1.1% vs. 6.6% in SL; P = 0.12). Functional outcomes (mRS 0–1) at last follow-up were comparable (82% in SLS vs. 86% in SL; P = 0.41). In the treatment of narrow-neck intracranial aneurysms, the SLS WEB device was associated with significantly lower rates of major device compaction compared to the SL device. Reduced compaction may lead to a lower need for retreatment. Overall imaging outcomes and safety profiles were similar between the two devices.