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Introduction <p>Custom-made cranioplasty can be performed using various heterologous materials, each associated with a distinct complication profile. This systematic review focuses on infections, the most common complication following cranioplasty.</p> Materials and methods <p>A systematic review of the available literature was conducted to identify infection and explantation rates associated with materials used in custom-made heterologous cranioplasty. A comprehensive search of PubMed/MEDLINE, Scopus, and Embase databases yielded 3437 articles. After screening, 43 articles met the inclusion criteria and data on study parameters, patient populations, and infection characteristics were extracted.</p> Results <p>Forty-three articles were selected and included in this review, analyzing a total of 3260 implanted cranioplasties, divided by material as follows: 931 titanium, 1227 hydroxyapatite, 680 PMMA, 379 PEEK, and 143 composites. The cumulative infection and explantation rates were: 8.2% and 3.7% for titanium, 6.7% and 5.3% for hydroxyapatite, 14.9% and 6.1% for PMMA, 11.1% and 3.8% for PEEK, and 4.2% and 6.2% for composites. Importantly, the follow-up duration varied significantly among materials. Studies involving titanium and composites had the shortest follow-up, potentially underestimating infection rates, while studies on PMMA and hydroxyapatite had the longest follow-up, providing more robust estimates.</p> Conclusions <p>This review confirms general trends in infection rates among cranioplasty materials and emphasizes the critical role of follow-up duration in interpreting complication rate. Differences in study design and reporting standards limit direct comparison between materials. Future research should adopt standardized follow-up thresholds and uniform outcome definitions to enable reliable cross-material comparisons.</p>

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Infection rates following custom-made cranioplasty using heterologous materials: insights from a systematic review on 3260 patients with a focus on follow-up length

  • 期刊论文

  • 发表日期：

    2025年9月19日

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  • Francesca Faedo,
  • Ismail Zaed,
  • Andrea Pizzi,
  • Corrado Iaccarino,
  • Franco Servadei

摘要

Introduction

Custom-made cranioplasty can be performed using various heterologous materials, each associated with a distinct complication profile. This systematic review focuses on infections, the most common complication following cranioplasty.

Materials and methods

A systematic review of the available literature was conducted to identify infection and explantation rates associated with materials used in custom-made heterologous cranioplasty. A comprehensive search of PubMed/MEDLINE, Scopus, and Embase databases yielded 3437 articles. After screening, 43 articles met the inclusion criteria and data on study parameters, patient populations, and infection characteristics were extracted.

Results

Forty-three articles were selected and included in this review, analyzing a total of 3260 implanted cranioplasties, divided by material as follows: 931 titanium, 1227 hydroxyapatite, 680 PMMA, 379 PEEK, and 143 composites. The cumulative infection and explantation rates were: 8.2% and 3.7% for titanium, 6.7% and 5.3% for hydroxyapatite, 14.9% and 6.1% for PMMA, 11.1% and 3.8% for PEEK, and 4.2% and 6.2% for composites. Importantly, the follow-up duration varied significantly among materials. Studies involving titanium and composites had the shortest follow-up, potentially underestimating infection rates, while studies on PMMA and hydroxyapatite had the longest follow-up, providing more robust estimates.

Conclusions

This review confirms general trends in infection rates among cranioplasty materials and emphasizes the critical role of follow-up duration in interpreting complication rate. Differences in study design and reporting standards limit direct comparison between materials. Future research should adopt standardized follow-up thresholds and uniform outcome definitions to enable reliable cross-material comparisons.