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<p>Cancer persists as a leading global cause of mortality. Within this complex landscape, transcription factors (TFs) are pivotal drivers, orchestrating tumor cell phenotypic plasticity and remodeling the immunosuppressive tumor microenvironment through downstream gene regulation. Beyond its established roles in embryonic development and angiogenesis, the SOX (<i>SRY</i>-related HMG-box) family member SOX18 has now been implicated as a critical oncogenic player. Mounting evidence reveals SOX18 overexpression across diverse malignancies, where it actively drives key malignant hallmarks including tumor initiation, metastatic progression, and immune evasion. This review synthesizes the latest advances elucidating the multifaceted roles of SOX18 in cancer pathogenesis. Our aim is to highlight SOX18’s potential as a novel therapeutic target and guide the development of innovative intervention strategies to optimize clinical cancer management.</p>

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SOX18 at the crossroads of cancer: integrating signaling pathways to drive malignant transformation and immune evasion

  • 期刊论文

  • 发表日期：

    2026年3月20日

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  • Xiaoli Liu,
  • Jie Liang,
  • Xiao Wang,
  • Wei Li,
  • Yi Liu,
  • Luoyang Wang,
  • Mengting Zhou,
  • Guixian Liu,
  • Meiying Song,
  • Li Zhang,
  • Yanyan Yang,
  • Bei Zhang

摘要

Cancer persists as a leading global cause of mortality. Within this complex landscape, transcription factors (TFs) are pivotal drivers, orchestrating tumor cell phenotypic plasticity and remodeling the immunosuppressive tumor microenvironment through downstream gene regulation. Beyond its established roles in embryonic development and angiogenesis, the SOX (SRY-related HMG-box) family member SOX18 has now been implicated as a critical oncogenic player. Mounting evidence reveals SOX18 overexpression across diverse malignancies, where it actively drives key malignant hallmarks including tumor initiation, metastatic progression, and immune evasion. This review synthesizes the latest advances elucidating the multifaceted roles of SOX18 in cancer pathogenesis. Our aim is to highlight SOX18’s potential as a novel therapeutic target and guide the development of innovative intervention strategies to optimize clinical cancer management.