Scholarlink

<p>Hypertension is a major global cardiovascular disorder characterized by complex and multifactorial pathogenesis. Although numerous antihypertensive therapies are available, a considerable proportion of patients continue to exhibit inadequate blood pressure control. Emerging evidence underscores the central role of mitochondrial dysfunction in the development and progression of hypertension. As regulators of energy metabolism, redox balance, calcium signaling, and cell survival, mitochondria play a significant role in maintaining vascular and neuronal homeostasis. Mitochondrial abnormalities-such as excessive ROS production, impaired mitophagy, disrupted fusion and fission dynamics, and calcium dysregulation—can amplify vascular dysfunction and sympathetic overactivation, thereby elevating blood pressure. This review summarizes current advances in mitochondrial pathophysiology in hypertension and discusses mitochondrial-targeted therapeutic strategies. Natural products derived from traditional Chinese medicine (e.g., apigenin, berberine, curcumin) and Western compounds (e.g., MitoTEMPO, empagliflozin, Mdivi-1) show promise in mitigating mitochondrial stress and lowering blood pressure. A deeper understanding of mitochondria-centered mechanisms may offer novel opportunities for precision therapy, particularly in resistant hypertension.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mitochondrial dysfunction in hypertension: mechanistic pathways and therapeutic implications

  • 期刊论文

  • 发表日期：

    2026年2月9日

查看全文
  • Jiao Tian,
  • Lin Yi,
  • Yuyuan Lu,
  • Yushun Kou,
  • Lingna Zhang,
  • Penghui Jin,
  • Xiaoke Wang,
  • Tao Wu,
  • Xin Yang,
  • Yiyuan Wang,
  • Ruiling Ma

摘要

Hypertension is a major global cardiovascular disorder characterized by complex and multifactorial pathogenesis. Although numerous antihypertensive therapies are available, a considerable proportion of patients continue to exhibit inadequate blood pressure control. Emerging evidence underscores the central role of mitochondrial dysfunction in the development and progression of hypertension. As regulators of energy metabolism, redox balance, calcium signaling, and cell survival, mitochondria play a significant role in maintaining vascular and neuronal homeostasis. Mitochondrial abnormalities-such as excessive ROS production, impaired mitophagy, disrupted fusion and fission dynamics, and calcium dysregulation—can amplify vascular dysfunction and sympathetic overactivation, thereby elevating blood pressure. This review summarizes current advances in mitochondrial pathophysiology in hypertension and discusses mitochondrial-targeted therapeutic strategies. Natural products derived from traditional Chinese medicine (e.g., apigenin, berberine, curcumin) and Western compounds (e.g., MitoTEMPO, empagliflozin, Mdivi-1) show promise in mitigating mitochondrial stress and lowering blood pressure. A deeper understanding of mitochondria-centered mechanisms may offer novel opportunities for precision therapy, particularly in resistant hypertension.