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<p>Totipotency, the capacity of a single cell to regenerate a complete organism, is the central to plant developmental plasticity and underpins plant regeneration via somatic embryogenesis and/or organogenesis, a cornerstone of plant biotechnology, including transgenics and genome editing. A recent study, by using time-resolved single-cell and spatial transcriptomic analysis, Tang et al. 2025 shows that LEAFY COTYLEDON2 (LEC2) can reprogram a defined epidermal lineage, SPEECHLESS (SPCH)-expressing meristemoid mother cells (MMCs), into somatic embryo founder cells (SEFCs) by cooperating with SPCH to activate local auxin biosynthesis (TAA1/YUC4), producing a GMC-auxin transitional state that enables transcriptional and chromatin reconfiguration toward totipotency. This lineage-specific, auxin-driven route both refines conceptual models of plant reprogramming and offers practical levers to improve plant regeneration and transformation in crops.</p>

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LEC2, a key player for cell totipotency in somatic embryogenesis and plant regeneration

  • 期刊论文

  • 发表日期：

    2026年1月2日

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  • Haifang Dai,
  • Yueheng Lv,
  • Zihao Liu,
  • Lijie Li

摘要

Totipotency, the capacity of a single cell to regenerate a complete organism, is the central to plant developmental plasticity and underpins plant regeneration via somatic embryogenesis and/or organogenesis, a cornerstone of plant biotechnology, including transgenics and genome editing. A recent study, by using time-resolved single-cell and spatial transcriptomic analysis, Tang et al. 2025 shows that LEAFY COTYLEDON2 (LEC2) can reprogram a defined epidermal lineage, SPEECHLESS (SPCH)-expressing meristemoid mother cells (MMCs), into somatic embryo founder cells (SEFCs) by cooperating with SPCH to activate local auxin biosynthesis (TAA1/YUC4), producing a GMC-auxin transitional state that enables transcriptional and chromatin reconfiguration toward totipotency. This lineage-specific, auxin-driven route both refines conceptual models of plant reprogramming and offers practical levers to improve plant regeneration and transformation in crops.