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<p>The unreported peptide versicotide K (<b>1</b>), along with known averufin (<b>2</b>), 1′- hydroxyversicolorin B (<b>3</b>), averufanin (<b>4</b>), and sterigmatocystin (<b>5</b>), was isolated from the sponge-derived fungal strain <i>Aspergillus versicolor</i> 01NT- 1.5.1. Moreover, the new 6,8-dimethoxyaverythrin (<b>6</b>) and known averythrin (<b>7</b>) and sclerotiotide F (<b>8</b>) were isolated from another sponge-derived fungus <i>Aspergillus flavus</i> КMM 4695 (= VO49-48.3). The antimicrobial and cytotoxic activities of the isolated compounds were studied. The obtained data on the low cytotoxicity of averufanin (<b>4</b>) to normal HaCaT keratinocytes and H9c2 cardiomyocytes confirms its anticancer potential for future research. The significant activity of averythrin (<b>7</b>) against <i>Staphylococcus aureus</i> growth and biofilm formation (IC<sub>50</sub> of approximately 10&#xa0;µM) is the first. The anti-inflammatory activity of versicotide K (<b>1</b>) was predicted using the PASS online server. Moreover, SwissTargetPrediction services predicted COX2 as a possible target for <b>1</b>, and the interaction of <b>1</b> with COX2 was calculated using a molecular docking approach. In in vitro experiments, versicotide K (<b>1</b>) reduced <i>S. aureus</i> infection and ischemia/reperfusion damage of H9c2 cells and prevented TNF-α induced damage of H9c2 cardiomyocytes by 24%, confirming its anti-inflammatory properties.</p>

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Versicotide K and Other Secondary Metabolites from the Two Strains of Sponge-Derived Fungi of Aspergillus Genus

  • 期刊论文

  • 发表日期：

    2025年10月22日

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  • Olga O. Khmel,
  • Ekaterina A. Yurchenko,
  • Ekaterina A. Chingizova,
  • Phan Thi Hoai Trinh,
  • Ngo Thi Duy Ngoc,
  • Vo Thi Dieu Trang,
  • Yulia V. Khudyakova,
  • Valeria V. Kurilenko,
  • Roman S. Popov,
  • Konstantin A. Drozdov,
  • Alexandr S. Antonov,
  • Anton N. Yurchenko

摘要

The unreported peptide versicotide K (1), along with known averufin (2), 1′- hydroxyversicolorin B (3), averufanin (4), and sterigmatocystin (5), was isolated from the sponge-derived fungal strain Aspergillus versicolor 01NT- 1.5.1. Moreover, the new 6,8-dimethoxyaverythrin (6) and known averythrin (7) and sclerotiotide F (8) were isolated from another sponge-derived fungus Aspergillus flavus КMM 4695 (= VO49-48.3). The antimicrobial and cytotoxic activities of the isolated compounds were studied. The obtained data on the low cytotoxicity of averufanin (4) to normal HaCaT keratinocytes and H9c2 cardiomyocytes confirms its anticancer potential for future research. The significant activity of averythrin (7) against Staphylococcus aureus growth and biofilm formation (IC50 of approximately 10 µM) is the first. The anti-inflammatory activity of versicotide K (1) was predicted using the PASS online server. Moreover, SwissTargetPrediction services predicted COX2 as a possible target for 1, and the interaction of 1 with COX2 was calculated using a molecular docking approach. In in vitro experiments, versicotide K (1) reduced S. aureus infection and ischemia/reperfusion damage of H9c2 cells and prevented TNF-α induced damage of H9c2 cardiomyocytes by 24%, confirming its anti-inflammatory properties.