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<p>Soft corals of the genus <i>Caementabunda</i> (synonym <i>Cespitularia</i>) were reported to possess terpenoids with various carbon skeletons. In this research, samples of <i>C. hypotentaculata</i> were collected before and after spawning (in May and August) to compare their secondary metabolites. With the aid of LC–MS/MS molecule networking, a series of unknown verticillane-type diterpenoids were targeted. After repeated column chromatography, five new verticillane-type diterpenoids (<b>1</b>‒<b>5</b>) and one new eudesmanolide-type sesquiterpenoid (<b>6</b>), together with twenty-four known compounds (<b>7</b>‒<b>30</b>), were identified from the Formosan soft coral <i>C. hypotentaculata</i>. Their structures were determined by UV, IR, MS, and NMR analyses, together with the biogenetic considerations of terpenoids. Our pharmacological study showed that the ethanol extract of <i>C. hypotentaculata</i> exhibited antiangiogenic potential against human endothelial progenitor cells. Among all isolated compounds, compound <b>30</b> demonstrated a moderate antiangiogenic effect with an IC<sub>50</sub> value of 29.0 ± 0.6&#xa0;μM.</p>

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Terpenoids with Antiangiogenic Activity from Formosan Soft Coral Caementabunda hypotentaculata

  • 期刊论文

  • 发表日期：

    2025年4月3日

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  • Hsin Huang,
  • Chen-Yu Yang,
  • Shih-Wei Wang,
  • Limbadri Salendra,
  • Shu-Rong Chen,
  • Tzi-Yi Ke,
  • Yu-Liang Yang,
  • Yu-Chi Lin,
  • Yuan-Bin Cheng

摘要

Soft corals of the genus Caementabunda (synonym Cespitularia) were reported to possess terpenoids with various carbon skeletons. In this research, samples of C. hypotentaculata were collected before and after spawning (in May and August) to compare their secondary metabolites. With the aid of LC–MS/MS molecule networking, a series of unknown verticillane-type diterpenoids were targeted. After repeated column chromatography, five new verticillane-type diterpenoids (1‒5) and one new eudesmanolide-type sesquiterpenoid (6), together with twenty-four known compounds (7‒30), were identified from the Formosan soft coral C. hypotentaculata. Their structures were determined by UV, IR, MS, and NMR analyses, together with the biogenetic considerations of terpenoids. Our pharmacological study showed that the ethanol extract of C. hypotentaculata exhibited antiangiogenic potential against human endothelial progenitor cells. Among all isolated compounds, compound 30 demonstrated a moderate antiangiogenic effect with an IC50 value of 29.0 ± 0.6 μM.