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<p>Microvascular anastomosis is a fundamental technique in microsurgery, and the development of suitable cuff tubes is crucial for improving the surgical efficiency and long-term vascular patency. Polyimide, a high-performance polymer, offers excellent thermal stability, chemical resistance, and biocompatibility, making it a promising candidate for microvascular applications. In this study, we employed a dry-jet wet-spinning method using P84 polyimide to fabricate polyimide (PI) cuff tubes. The effects of bore fluid flowrate, dope flowrate, and take-up speed on the structural morphology and mechanical properties of the tubes were systematically investigated. Heat treatment was applied to optimize the mechanical performance. Heat treatment above the glass transition temperature significantly enhances the solvent resistance and mechanical strength without altering the chemical structure. The PI cuff tubes demonstrated negligible cytotoxicity and hemolysis, no genotoxic or immunogenic effects, and no systemic organ toxicity. <i>In vivo</i> implantation showed sustained vascular patency and no local inflammatory response for up to 90 days post-operatively. The fabricated PI cuff tubes possessed high structural integrity, tunable flexibility, ideal mechanical properties, excellent biosafety, and outstanding <i>in vivo</i> performance, suggesting their strong potential for future clinical translation in microvascular anastomosis and vascular graft applications.</p>

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High-performance Polyimide Cuff Tube with Tunable Mechanics and Long-term Biocompatibility for Microvascular Anastomosis

  • 期刊论文

  • 发表日期：

    2026年5月27日

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  • Hui Su,
  • Zhou-Quan Sun,
  • Yu-Cheng Qiu,
  • Yuan-Yuan Zhang,
  • Jing Luo,
  • Fei Liu,
  • Jun Yang,
  • Xian-Yu Zhou,
  • Yue Zhang,
  • Yu-Mei Zhang

摘要

Microvascular anastomosis is a fundamental technique in microsurgery, and the development of suitable cuff tubes is crucial for improving the surgical efficiency and long-term vascular patency. Polyimide, a high-performance polymer, offers excellent thermal stability, chemical resistance, and biocompatibility, making it a promising candidate for microvascular applications. In this study, we employed a dry-jet wet-spinning method using P84 polyimide to fabricate polyimide (PI) cuff tubes. The effects of bore fluid flowrate, dope flowrate, and take-up speed on the structural morphology and mechanical properties of the tubes were systematically investigated. Heat treatment was applied to optimize the mechanical performance. Heat treatment above the glass transition temperature significantly enhances the solvent resistance and mechanical strength without altering the chemical structure. The PI cuff tubes demonstrated negligible cytotoxicity and hemolysis, no genotoxic or immunogenic effects, and no systemic organ toxicity. In vivo implantation showed sustained vascular patency and no local inflammatory response for up to 90 days post-operatively. The fabricated PI cuff tubes possessed high structural integrity, tunable flexibility, ideal mechanical properties, excellent biosafety, and outstanding in vivo performance, suggesting their strong potential for future clinical translation in microvascular anastomosis and vascular graft applications.