<p>The rapid development of the Internet of Things and wearable technologies has created substantial demand for stretchable optoelectronic devices. Among these, intrinsically stretchable organic optoelectronic devices are emerging as key technologies for applications in wearable electronics, electronic skin, and health monitoring. This review systematically summarizes the recent progress in this field. We first outline two primary strategies for achieving stretchability: structural engineering (buckling and island-bridge configurations) and intrinsic material design. The review focuses on the latter, providing a comprehensive overview of the design of key components, including insulators, electrodes, and optoelectronic functional layers. Specifically, the design principles for intrinsically stretchable semiconductor active layers are elaborated with a focus on molecular engineering and composite material strategies. Furthermore, we summarize the performance optimization and applications of representative devices, such as organic photodiodes (OPDs), organic phototransistors (OPTs), organic photovoltaics (OPVs), organic light-emitting diodes (OLEDs), and organic light-emitting electrochemical cells (OLECs). The potential of these devices for integrated systems, including human-machine interaction, neuromorphic electronics, and wearable health monitors, is also explored. Finally, the current challenges and future research directions are discussed.</p>