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<p>Cancer has been recognized as one of the leading causes of mortality for decades. Magnetic resonance imaging (MRI) is a powerful imaging technology that has been widely applied in tumor diagnosis. Herein, we report the synthesis of magnetic iron oxide nanoparticles (MIONs) functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid) (PTMPPMAA). Cytotoxicity assessment <i>via</i> the CCK-8 assay confirmed the low toxicity of the nanoparticles. MRI results showed excellent negative contrast enhancement. Bio-distribution study indicated gradual excretion of the nanoparticles. These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as <i>T</i><sub>2</sub>-weighted contrast agents for MRI.</p>

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Superparamagnetic Iron Oxide Nanoparticles Prepared with Multidentate Thioether Polymer Ligand for Magnetic Resonance Imaging

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Chang Gao,
  • Chen-Yang Xiang,
  • Jiao-Jiao Guo,
  • Peng-Rui Song,
  • Zhi-Yan Lu,
  • Chun-Sheng Xiao,
  • Irshad Hussain,
  • Wen Fan,
  • Xiu-Dong Shi,
  • Wei Yan

摘要

Cancer has been recognized as one of the leading causes of mortality for decades. Magnetic resonance imaging (MRI) is a powerful imaging technology that has been widely applied in tumor diagnosis. Herein, we report the synthesis of magnetic iron oxide nanoparticles (MIONs) functionalized with multidentate thioether polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(methacrylic acid) (PTMPPMAA). Cytotoxicity assessment via the CCK-8 assay confirmed the low toxicity of the nanoparticles. MRI results showed excellent negative contrast enhancement. Bio-distribution study indicated gradual excretion of the nanoparticles. These MIONs@PTMP-PMAA exhibit strong negative contrast enhancement and present great potential as T2-weighted contrast agents for MRI.