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<p>Magnetic resonance imaging (MRI) is one of the most widely used diagnostic techniques. Iron oxide nanoparticles, as a promising kind of contrast agents, have attracted intense research interest due to their low toxicity and superparamagnetism. However, it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity, excellent water solubility and biocompatibility. In this paper, a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(<i>N</i>-vinyl-2-pyrrolidone) (PTMP-PVP) was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100 °C. The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution, and they were found to be biocompatible as determined through CCK-8 assay and histology analysis. <i>In vivo</i> MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective <i>T</i><sub>2</sub>-weighted MRI contrast agent.</p>

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Water-soluble Polymer Ligand Mediated Synthesis of Superparamagnetic Iron Oxide Nanoparticles for Magnetic Resonance Imaging

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Ping-Ting Gong,
  • Jiao-Jiao Guo,
  • Chang Gao,
  • Wei-Tao Yang,
  • Chun-Sheng Xiao,
  • Yi Xu,
  • Yue Yao,
  • Irshad Hussain,
  • Wen Fan,
  • Wei Yan

摘要

Magnetic resonance imaging (MRI) is one of the most widely used diagnostic techniques. Iron oxide nanoparticles, as a promising kind of contrast agents, have attracted intense research interest due to their low toxicity and superparamagnetism. However, it is still a great challenge to prepare ideal iron oxide based contrast agents with high uniformity, excellent water solubility and biocompatibility. In this paper, a novel water-soluble polymer ligand pentaerythritol tetrakis 3-mercaptopropionate-poly(N-vinyl-2-pyrrolidone) (PTMP-PVP) was used as a capping reagent to prepare iron oxide nanoparticles MIONs@PTMP-PVP through one-step co-precipitation of iron precursors in aqueous solution at 100 °C. The obtained nanoparticles MIONs@PTMP-PVP had a small size and narrow size distribution, and they were found to be biocompatible as determined through CCK-8 assay and histology analysis. In vivo MRI study demonstrated that the obtained MIONs@PTMP-PVP can be potentially used as an effective T2-weighted MRI contrast agent.