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<p>Glucose, ascorbic acid (AA), uric acid (UA), and dopamine (DA) are vital biomarkers whose dynamic concentrations correlate with critical diseases; however, multiplexed detection remains challenging for conventional electrochemical sensors because of their limited sensitivity and selectivity. Here, we present a millimeter-scale all-poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) organic electrochemical transistor (OECT) platform that integrates dual-mode sensing with enzyme/metal-free operation for ultrasensitive biomarker monitoring. By engineering polycrystalline PEDOT:PSS channels <i>via</i> H<sub>2</sub>SO<sub>4</sub> post-treatment, the device achieves record-high conductivity (about (2312.0±29.9) S·cm<sup>−1</sup>), maximum transconductance (about (2.82±0.12) mS), and on/off ratio (about 210.0±7.8), enabling signal amplification at low gate voltages. The dual-mode strategy combines the selectivity of electrochemistry with the sensitivity of OECTs, realizing simultaneous detection of glucose, AA, UA, and DA with clinical-level sensitivity: detection limits down to 8 nmol·L<sup>−1</sup> (glucose), 0.5 nmol·L<sup>−1</sup> (AA), 5 nmol·L<sup>−1</sup> (DA), and 0.5 nmol·L<sup>−1</sup> (UA). Validation using human urine samples yielded recovery rates of 94%–114%. This flexible sensing platform provides a new pathway for the development of wearable biosensors for precision diagnostics.</p>

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Dual-mode All-PEDOT:PSS Organic Electrochemical Transistors: Enzyme/Metal-free Platform for Ultrasensitive Multiplexed Biosensing of Biomarkers

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Xiao-Fang Liu,
  • Jia-Hui Lai,
  • Cheng Liu,
  • Pei-Pei Liu,
  • Yin-Xiu Zuo,
  • Huan-Huan Qiu,
  • Rong-Ri Tan,
  • Jing Li,
  • Yu-Kou Du,
  • Jing-Kun Xu,
  • Feng-Xing Jiang

摘要

Glucose, ascorbic acid (AA), uric acid (UA), and dopamine (DA) are vital biomarkers whose dynamic concentrations correlate with critical diseases; however, multiplexed detection remains challenging for conventional electrochemical sensors because of their limited sensitivity and selectivity. Here, we present a millimeter-scale all-poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) organic electrochemical transistor (OECT) platform that integrates dual-mode sensing with enzyme/metal-free operation for ultrasensitive biomarker monitoring. By engineering polycrystalline PEDOT:PSS channels via H2SO4 post-treatment, the device achieves record-high conductivity (about (2312.0±29.9) S·cm−1), maximum transconductance (about (2.82±0.12) mS), and on/off ratio (about 210.0±7.8), enabling signal amplification at low gate voltages. The dual-mode strategy combines the selectivity of electrochemistry with the sensitivity of OECTs, realizing simultaneous detection of glucose, AA, UA, and DA with clinical-level sensitivity: detection limits down to 8 nmol·L−1 (glucose), 0.5 nmol·L−1 (AA), 5 nmol·L−1 (DA), and 0.5 nmol·L−1 (UA). Validation using human urine samples yielded recovery rates of 94%–114%. This flexible sensing platform provides a new pathway for the development of wearable biosensors for precision diagnostics.