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<p>Early knee osteoarthritis (KOA) is characterized by progressive degeneration of the articular cartilage, synovial inflammation, and excessive accumulation of reactive oxygen species (ROS). At present, intra-articular injection of hyaluronic acid (HA) is widely used to alleviate symptoms; however, its lubrication persistence, antioxidant, and anti-inflammatory abilities are limited, and it is difficult to effectively delay the early process of cartilage degeneration. Based on this, hyaluronic acid-<i>g</i>-lipoic acid (HA-LA) was synthesized by esterification reaction, and HA-LA microspheres were prepared by a reversed-phase emulsion method, which was combined with a macromolecular HA-LA solution to form injectable hydrogels. The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-<i>g</i>-lipoic acid microspheres (HA-LA MS) for the treatment of KOA and to verify its injectability, lubricity, reactive oxygen species (ROS) scavenging ability, and anti-inflammatory effects. The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability, and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect. <i>In vitro</i> experiments have shown that the hydrogel can efficiently scavenge ROS, reduce the expression of inflammatory factors, and is non-cytotoxic. The HA-LA MS injectable hydrogel has excellent lubricity, ROS scavenging ability, and anti-inflammatory effects <i>in vivo</i>, which can effectively delay the degeneration of early KOA cartilage, and its efficacy is significantly better than that of traditional hyaluronic acid, making it a promising intra-articular injection preparation.</p>

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Study on Hyaluronic Acid-g-lipoic acid Microsphere-based Injectable Hydrogel for Treating Early Knee Osteoarthritis

  • 期刊论文

  • 发表日期：

    2026年1月22日

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  • Mu-Zhi Zhang,
  • Jia-Tian Qian,
  • Da-Wei Niu,
  • Yan-Cheng Chen,
  • Shi-Ao Li,
  • Jiu-Jiang Zeng,
  • Kun-Xi Zhang,
  • Yan-Li Song,
  • Pei-Liang Fu

摘要

Early knee osteoarthritis (KOA) is characterized by progressive degeneration of the articular cartilage, synovial inflammation, and excessive accumulation of reactive oxygen species (ROS). At present, intra-articular injection of hyaluronic acid (HA) is widely used to alleviate symptoms; however, its lubrication persistence, antioxidant, and anti-inflammatory abilities are limited, and it is difficult to effectively delay the early process of cartilage degeneration. Based on this, hyaluronic acid-g-lipoic acid (HA-LA) was synthesized by esterification reaction, and HA-LA microspheres were prepared by a reversed-phase emulsion method, which was combined with a macromolecular HA-LA solution to form injectable hydrogels. The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres (HA-LA MS) for the treatment of KOA and to verify its injectability, lubricity, reactive oxygen species (ROS) scavenging ability, and anti-inflammatory effects. The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability, and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect. In vitro experiments have shown that the hydrogel can efficiently scavenge ROS, reduce the expression of inflammatory factors, and is non-cytotoxic. The HA-LA MS injectable hydrogel has excellent lubricity, ROS scavenging ability, and anti-inflammatory effects in vivo, which can effectively delay the degeneration of early KOA cartilage, and its efficacy is significantly better than that of traditional hyaluronic acid, making it a promising intra-articular injection preparation.