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<p>Liver is a vital organ in the human body and plays a central role in the metabolism and detoxification of endotoxins and exotoxins. Bilirubin is an endotoxin derived from hemoglobin (Hb). Removing excess bilirubin in the blood is crucial for the treatment of liver diseases. Hemoperfusion, which relies on adsorbents to efficiently adsorb toxins, is a widely applied procedure for the removal of blood toxins. To broaden and improve the range and performance of hemoperfusion adsorbents, we synthesized cationic hyper crosslinked polymers (HCPs) with strong affinity for bilirubin. This material exhibited outstanding adsorption performance, with a maximum adsorption capacity of 934 mg/g and a removal efficiency of 96%. Further investigation confirmed their excellent selectivity, reusability, and biocompatibility. These findings expand the potential applications of HCPs and provide insight into strategies for constructing promising hemoperfusion adsorbent materials.</p>

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Ionic Hyper Crosslinked Polymers as High Performance Hemoperfusion Adsorbent for Efficient Removal of Excessive Bilirubin

  • 期刊论文

  • 发表日期：

    2025年12月25日

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  • Hong-Xiang Yin,
  • Yue-Yuan Xiao,
  • Yu-Cheng Cai,
  • Shuai-Lin He,
  • Yang Wang,
  • Gang-Shen Zhang,
  • Cheng Zhang,
  • Bi-En Tan,
  • Irshad Hussain,
  • Wei Yan

摘要

Liver is a vital organ in the human body and plays a central role in the metabolism and detoxification of endotoxins and exotoxins. Bilirubin is an endotoxin derived from hemoglobin (Hb). Removing excess bilirubin in the blood is crucial for the treatment of liver diseases. Hemoperfusion, which relies on adsorbents to efficiently adsorb toxins, is a widely applied procedure for the removal of blood toxins. To broaden and improve the range and performance of hemoperfusion adsorbents, we synthesized cationic hyper crosslinked polymers (HCPs) with strong affinity for bilirubin. This material exhibited outstanding adsorption performance, with a maximum adsorption capacity of 934 mg/g and a removal efficiency of 96%. Further investigation confirmed their excellent selectivity, reusability, and biocompatibility. These findings expand the potential applications of HCPs and provide insight into strategies for constructing promising hemoperfusion adsorbent materials.