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<p>Photobiomodulation (PBM) has been shown to protect pancreatic islets under inflammatory or metabolic stress, but its effects during hypoxia-reperfusion remain unclear. We evaluated PBM applied as preconditioning or during hypoxia-reperfusion in MIN6 cells and rodent islets. Hypoxia significantly reduced viability and glucose-stimulated insulin secretion, while PBM failed to prevent these alterations and did not modify mitochondrial parameters. These findings indicate that PBM efficacy is stress-dependent and suggest limited benefit in the context of hypoxia-reperfusion, where mitochondrial dysfunction appears minimal in islet cells.</p>

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Islet response to photobiomodulation varies with the nature of the stress: insights from hypoxia–reperfusion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月14日

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  • Quentin Perrier,
  • Sandrine Lablanche,
  • Cécile Moro

摘要

Photobiomodulation (PBM) has been shown to protect pancreatic islets under inflammatory or metabolic stress, but its effects during hypoxia-reperfusion remain unclear. We evaluated PBM applied as preconditioning or during hypoxia-reperfusion in MIN6 cells and rodent islets. Hypoxia significantly reduced viability and glucose-stimulated insulin secretion, while PBM failed to prevent these alterations and did not modify mitochondrial parameters. These findings indicate that PBM efficacy is stress-dependent and suggest limited benefit in the context of hypoxia-reperfusion, where mitochondrial dysfunction appears minimal in islet cells.