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<p>Cutaneous aging is characterized by gradual structural and functional alterations, including collagen breakdown and reduced elasticity. In recent years, several energy-based modalities have been introduced to address these changes. The aim of this study was to assess the effectiveness of a 675&#xa0;nm laser and microfocused ultrasound (MFU), applied individually or in combination, for the treatment of facial aging.&#xa0;This retrospective analysis included 115 patients, allocated into three groups: Group A (675&#xa0;nm laser), Group B (MFU), and Group C (combined protocol). Efficacy was evaluated through the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months following treatment.&#xa0;At the 6-month evaluation, individuals treated with the combined protocol exhibited a more pronounced improvement in wrinkle reduction (FWS: from 1.88 to 1.13) and laxity reduction (BGP: from 2.78 to 1.55) compared with either single-treatment group. No major side effects were observed.&#xa0;The combined application of the 675&#xa0;nm laser and MFU appears to potentiate collagen remodeling and skin tightening more effectively than monotherapy. Further prospective studies are needed to validate these results and further clarify the molecular pathways involved.</p>

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Dual-modality approach with 675 nm laser and microfocused ultrasound for facial aging: retrospective evaluation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月5日

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  • Elena Zappia,
  • Corinna Genovesi,
  • Domenico Piccolo,
  • Federica Trovato,
  • Martina Tolone,
  • Luca Gargano,
  • Alessandro Clementi,
  • Giuseppe Lodi,
  • Annunziata Dattola,
  • Steven Paul Nisticò

摘要

Cutaneous aging is characterized by gradual structural and functional alterations, including collagen breakdown and reduced elasticity. In recent years, several energy-based modalities have been introduced to address these changes. The aim of this study was to assess the effectiveness of a 675 nm laser and microfocused ultrasound (MFU), applied individually or in combination, for the treatment of facial aging. This retrospective analysis included 115 patients, allocated into three groups: Group A (675 nm laser), Group B (MFU), and Group C (combined protocol). Efficacy was evaluated through the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months following treatment. At the 6-month evaluation, individuals treated with the combined protocol exhibited a more pronounced improvement in wrinkle reduction (FWS: from 1.88 to 1.13) and laxity reduction (BGP: from 2.78 to 1.55) compared with either single-treatment group. No major side effects were observed. The combined application of the 675 nm laser and MFU appears to potentiate collagen remodeling and skin tightening more effectively than monotherapy. Further prospective studies are needed to validate these results and further clarify the molecular pathways involved.