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Purpose <p>This study aimed to evaluate the effectiveness of the laser-assisted new attachment procedure (LANAP) and low-level laser therapy (LLLT) on clinical, biochemical, and radiographic parameters when applied alongside scaling and root planing (SRP).</p> Methods <p>The study was designed as a randomized controlled, single-blind, parallel trial involving 68 patients diagnosed with periodontitis. The participants were divided into three groups: Group 1: SRP (control), Group 2: LANAP, and Group 3: LLLT. Clinical measurements, gingival crevicular fluid (GCF) samples, and standard periapical radiographs were obtained pre-treatment and at one- and three-month follow-ups. In GCF, interleukin-1beta (IL-1β), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) were analyzed.</p> Results <p>In moderate (4–6&#xa0;mm) and deep pockets (≥ 7&#xa0;mm), laser-treated groups showed a significant reduction in pocket depth (PD) and clinical attachment level (CAL) compared to the control group. However, there were no statistically significant differences in biochemical markers between the groups. Group 2 demonstrated significant bone filling compared to the control group.</p> Conclusion <p>In deep pockets, laser-treated groups provide additional benefits to SRP. The application of LLLT positively affected recession (REC).</p> <p><b>Trial registration number:</b> NCT04694222</p> <p><b>Date of registration:</b> 01/01/2021</p>

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Evaluating efficacy of laser-assisted new attachment procedure and adjunctive low-level laser therapy in treating periodontitis: A single-blind randomized controlled clinical study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月22日

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  • Fadime Kaya Dadas,
  • Selin Genc Kocaayan,
  • Mehmet Saglam,
  • Omer Faruk Dadas,
  • Serhat Koseoglu

摘要

Purpose

This study aimed to evaluate the effectiveness of the laser-assisted new attachment procedure (LANAP) and low-level laser therapy (LLLT) on clinical, biochemical, and radiographic parameters when applied alongside scaling and root planing (SRP).

Methods

The study was designed as a randomized controlled, single-blind, parallel trial involving 68 patients diagnosed with periodontitis. The participants were divided into three groups: Group 1: SRP (control), Group 2: LANAP, and Group 3: LLLT. Clinical measurements, gingival crevicular fluid (GCF) samples, and standard periapical radiographs were obtained pre-treatment and at one- and three-month follow-ups. In GCF, interleukin-1beta (IL-1β), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) were analyzed.

Results

In moderate (4–6 mm) and deep pockets (≥ 7 mm), laser-treated groups showed a significant reduction in pocket depth (PD) and clinical attachment level (CAL) compared to the control group. However, there were no statistically significant differences in biochemical markers between the groups. Group 2 demonstrated significant bone filling compared to the control group.

Conclusion

In deep pockets, laser-treated groups provide additional benefits to SRP. The application of LLLT positively affected recession (REC).

Trial registration number: NCT04694222

Date of registration: 01/01/2021