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<p>This brief report aimed to investigate the optical absorbance spectra of normal, dysplastic, and malignant epithelial cell lines under normal and nutritional stress conditions. HaCAT (keratinocyte), DOK (oral dysplastic), and oral squamous cell carcinoma (OSCC) cell lines (CA1, Luc4, SCC9) were evaluated regarding their optical absorbance after culture with 0–10% fetal bovine serum. Absorbance measurements indicated that HaCAT under serum starvation exhibited higher absorbance at blue (430&#xa0;nm) and near-infrared (906&#xa0;nm) wavelengths. DOK showed absorption at 440&#xa0;nm and 945&#xa0;nm. OSCC cells showed absorption peaks at blue (400–428&#xa0;nm) and near-infrared. These findings highlight the importance of tailoring PBM parameters to individual needs to achieve optimal absorption and effectiveness. Moreover, the higher absorption peaks in the blue region support further studies to elucidate the potential use of blue light in oral dysplastic lesions and OSCC.</p>

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Effect of nutritional stress and serum starvation on the optical absorbance of normal and malignant epithelial cell lines

  • 期刊论文

  • 发表日期：

    2025年1月23日

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  • Juliana Stephan Nobile,
  • Daniele Heguedusch,
  • Giovanna Lopes Carvalho,
  • Daniela Fátima Teixeira Silva,
  • Rebeca Boltes Cecatto,
  • Rodrigo Labat Marcos,
  • Fabio Daumas Nunes,
  • Maria Fernanda Setúbal Destro Rodrigues

摘要

This brief report aimed to investigate the optical absorbance spectra of normal, dysplastic, and malignant epithelial cell lines under normal and nutritional stress conditions. HaCAT (keratinocyte), DOK (oral dysplastic), and oral squamous cell carcinoma (OSCC) cell lines (CA1, Luc4, SCC9) were evaluated regarding their optical absorbance after culture with 0–10% fetal bovine serum. Absorbance measurements indicated that HaCAT under serum starvation exhibited higher absorbance at blue (430 nm) and near-infrared (906 nm) wavelengths. DOK showed absorption at 440 nm and 945 nm. OSCC cells showed absorption peaks at blue (400–428 nm) and near-infrared. These findings highlight the importance of tailoring PBM parameters to individual needs to achieve optimal absorption and effectiveness. Moreover, the higher absorption peaks in the blue region support further studies to elucidate the potential use of blue light in oral dysplastic lesions and OSCC.