<p>The extensive use of Industry 4.0 technology in recent years has greatly improved sustainability achievements. Its ability to address environmental issues, promote sustainable economic and societal growth, encourage innovation, and fill knowledge gaps in the sector makes the research noteworthy and innovative. In order to fully execute the Sustainability 4.0 advancements in developing economies, this research focuses on the enablers that would be necessary. After conducting a thorough analysis of the literature and its verification by inputs from experts with significant Industry 4.0 and sustainability knowledge, 26 enablers that facilitate the implementation of Sustainability 4.0 were identified. Subsequently, the Decision Making Trial and Evaluation Laboratory (DEMATEL) technique gave the appearance of having a significant impact on the selection of high to low-priority enablers for the implementation of Sustainability 4.0. Furthermore, from the standpoint of Sustainability 4.0 advancements, current results demonstrate the cause-and-effect relationships among enablers. Therefore, this study offers a strong theoretical foundation alongside practical suggestions that support manufacturing industries in implementing technologically sophisticated Sustainability 4.0, facilitating a smooth transition to Sustainability 4.0. By assessing their current state, industries may make progress toward implementing Sustainability 4.0 in developing economies. This study’s uniqueness is in its use of the DEMATEL approach to find the contextual linkages of Sustainability 4.0 enablers based on Industry 4.0 and sustainable manufacturing principles within the manufacturing industries.</p> Graphical Abstract <p></p>