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<p>Disseminated <i>Salmonella enterica</i> infections represent a severe form of non-typhoidal salmonellosis increasingly complicated by antimicrobial resistance. We describe a case of disseminated non-typhoidal <i>Salmonella</i> in a man presenting with septic shock concerning for a thoracoabdominal endovascular graft infection with involvement of the urinary and respiratory tracts and thoracic skeleton. Hybrid whole-genome sequencing identified <i>Salmonella enterica</i> serovar Dublin and two significant plasmids, an IncC multidrug resistance plasmid harboring <i>bla</i><sub>CMY−2</sub>, <i>bla</i><sub>TEM−206</sub>, <i>tet</i>(<i>A</i>), and <i>sul2</i> and an IncFII(S)/IncX1 virulence plasmid containing a <i>spvA</i>-<i>D</i>/<i>spvR</i> operon associated with systemic infection. This case highlights a potential food-borne or zoonotic acquisition of invasive, plasmid-mediated AmpC-producing <i>Salmonella</i> Dublin.</p>

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Disseminated multidrug-resistant Salmonella enterica serovar Dublin infection associated with plasmid-borne CMY-2 gene in a patient with travel to a farm in Mexico

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  • 发表日期：

    2026年5月12日

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  • Mackenzie E. Collins,
  • Lilian Fung,
  • Timothy F. Brewer,
  • Shangxin Yang

摘要

Disseminated Salmonella enterica infections represent a severe form of non-typhoidal salmonellosis increasingly complicated by antimicrobial resistance. We describe a case of disseminated non-typhoidal Salmonella in a man presenting with septic shock concerning for a thoracoabdominal endovascular graft infection with involvement of the urinary and respiratory tracts and thoracic skeleton. Hybrid whole-genome sequencing identified Salmonella enterica serovar Dublin and two significant plasmids, an IncC multidrug resistance plasmid harboring blaCMY−2, blaTEM−206, tet(A), and sul2 and an IncFII(S)/IncX1 virulence plasmid containing a spvA-D/spvR operon associated with systemic infection. This case highlights a potential food-borne or zoonotic acquisition of invasive, plasmid-mediated AmpC-producing Salmonella Dublin.