Scholarlink

Purpose <p>The 2022 Mpox epidemic introduced a new disease with distinct clinical features and risk factors, requiring dedicated care pathways for suspected cases. Understanding clinical forms is crucial to prevent overwhelming these pathways. We aimed to describe cases with suspected and confirmed Mpox during the epidemic and provide a detailed characterization of the different clinical forms.</p> Methods <p>We included all patients consulting for suspected Mpox between May and December 2022 at referral centers in the North of France. We compared cases with confirmed-Mpox to non-confirmed cases and described differential diagnoses. Proportions of differential diagnoses across epidemic phases were compared. Cases with confirmed-Mpox were described, and symptom associations were characterized using network models.</p> Results <p>Overall, 212 patients were included. Among them, 65% (<i>n</i> = 138/212) were confirmed for Mpox. Confirmed-case proportions differed between epidemic rise and decline (72% (<i>n</i> = 93/130) vs. 55% (<i>n</i> = 45/82); <i>p</i> = 0.020). The main differential diagnoses were bacterial skin infections, chickenpox, syphilis and herpetic infections. Among confirmed Mpox, 91% (<i>n</i> = 125/138) were men who have sex with men, 76% (<i>n</i> = 105/138) had multiple partners, 28% (<i>n</i> = 39/138) were living with HIV, and 36% (<i>n</i> = 50/138) were on PrEP. Extra-genital/anal cutaneous lesions were not associated with genital/anal cutaneous lesions. Some extra cutaneous symptoms clustered.</p> Conclusion <p>Clinical presentations of Mpox are polymorphic, which may explain the lack of correct referrals to dedicated structures. This polymorphism warrants further investigation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mpox: clinical patterns and implications for epidemic management – a cohort study

  • 期刊论文

  • 发表日期：

    2026年4月18日

查看全文
  • Edouard Massip,
  • Isabelle Alcaraz,
  • Fanny Vuotto,
  • Enagnon Kazali Alidjinou,
  • Véronique Baclet,
  • Nathalie Viget,
  • Michel Valette,
  • Séverine Duflos,
  • Karine Faure,
  • Delphine Staumont-Sallé,
  • Frédéric Dezoteux,
  • Olivier Robineau

摘要

Purpose

The 2022 Mpox epidemic introduced a new disease with distinct clinical features and risk factors, requiring dedicated care pathways for suspected cases. Understanding clinical forms is crucial to prevent overwhelming these pathways. We aimed to describe cases with suspected and confirmed Mpox during the epidemic and provide a detailed characterization of the different clinical forms.

Methods

We included all patients consulting for suspected Mpox between May and December 2022 at referral centers in the North of France. We compared cases with confirmed-Mpox to non-confirmed cases and described differential diagnoses. Proportions of differential diagnoses across epidemic phases were compared. Cases with confirmed-Mpox were described, and symptom associations were characterized using network models.

Results

Overall, 212 patients were included. Among them, 65% (n = 138/212) were confirmed for Mpox. Confirmed-case proportions differed between epidemic rise and decline (72% (n = 93/130) vs. 55% (n = 45/82); p = 0.020). The main differential diagnoses were bacterial skin infections, chickenpox, syphilis and herpetic infections. Among confirmed Mpox, 91% (n = 125/138) were men who have sex with men, 76% (n = 105/138) had multiple partners, 28% (n = 39/138) were living with HIV, and 36% (n = 50/138) were on PrEP. Extra-genital/anal cutaneous lesions were not associated with genital/anal cutaneous lesions. Some extra cutaneous symptoms clustered.

Conclusion

Clinical presentations of Mpox are polymorphic, which may explain the lack of correct referrals to dedicated structures. This polymorphism warrants further investigation.