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Purpose <p>We aimed to assess the positivity rate of HP infection tested by urea breath test or stool antigen from a large, nation-wide, population-based database, and to investigate the risk factors for infection.</p> Methods <p>A retrospective study from the database of the Clalit Health Service included all patients who underwent a urea breath test or stool antigen test for HP between the years 2000 and 2024. Demographic data, positivity rate, eradication treatment, and eradication failure were analyzed. Risk factors for HP positivity and for eradication failure were assessed using multivariate logistic regression.</p> Results <p>A total of 936,824 patients performed HP testing (56.4% urea breath test and 43.6% stool antigen). 191,838 (20.5%) of the subjects were Arab and 213,572 (22.8%) of them were current or former smoker. 420,709 (44.9%) were found to be HP positive including 40.2% in children aged 18 and younger. Abdominal pain as indication was found in 50.2%. Predictors for HP positivity included: age group 19–40 (OR 1.26, <i>p</i> &lt; 0.001), Arab ethnicity (OR 1.4), low socioeconomic status (OR 1.2), and smoking (OR 1.19). Among 16,966 patients with documented confirmatory retesting after treatment, the eradication failure rate was 27.4%. Age ≤ 18 years (OR 1.9), female sex (OR 1.087) and Arab ethnicity (OR 1.2) were identified as independent risk factors for eradication failure.</p> Conclusions <p>This large study highlights specific predictors for HP positivity and eradication failure, as well as the low retesting rate after treatment. These findings emphasize the need for special consideration in certain populations and greater awareness of the importance of HP eradication retesting.</p>

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Helicobacter pylori in Israel: real-life data from a large database on frequency of non-invasive testing, follow-up testing and risk factors for infection

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Naim Abu-Freha,
  • Daniel L. Cohen,
  • Alexander Fich,
  • Adi Nubani,
  • David Yardeni,
  • Muhammad Abu-Arar,
  • Athar Azbarga,
  • Aseel Azbarga,
  • Orian Simhon,
  • Doron Boltin

摘要

Purpose

We aimed to assess the positivity rate of HP infection tested by urea breath test or stool antigen from a large, nation-wide, population-based database, and to investigate the risk factors for infection.

Methods

A retrospective study from the database of the Clalit Health Service included all patients who underwent a urea breath test or stool antigen test for HP between the years 2000 and 2024. Demographic data, positivity rate, eradication treatment, and eradication failure were analyzed. Risk factors for HP positivity and for eradication failure were assessed using multivariate logistic regression.

Results

A total of 936,824 patients performed HP testing (56.4% urea breath test and 43.6% stool antigen). 191,838 (20.5%) of the subjects were Arab and 213,572 (22.8%) of them were current or former smoker. 420,709 (44.9%) were found to be HP positive including 40.2% in children aged 18 and younger. Abdominal pain as indication was found in 50.2%. Predictors for HP positivity included: age group 19–40 (OR 1.26, p < 0.001), Arab ethnicity (OR 1.4), low socioeconomic status (OR 1.2), and smoking (OR 1.19). Among 16,966 patients with documented confirmatory retesting after treatment, the eradication failure rate was 27.4%. Age ≤ 18 years (OR 1.9), female sex (OR 1.087) and Arab ethnicity (OR 1.2) were identified as independent risk factors for eradication failure.

Conclusions

This large study highlights specific predictors for HP positivity and eradication failure, as well as the low retesting rate after treatment. These findings emphasize the need for special consideration in certain populations and greater awareness of the importance of HP eradication retesting.