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Objective <p>Antibiotic resistance poses a major global public health threat. It compromises human health and increases healthcare burdens. The gut microbiota serves as a critical reservoir for antibiotic resistance genes (ARGs). It plays a pivotal role in the spread and evolution of antibiotic resistance. This study systematically analyzes the literature regarding on antibiotic resistance and gut microbiota from 1999 to 2024. It aims to elucidate global distribution, collaboration patterns, key contributors, current research hotspots, and future directions.</p> Methods <p>This study analyzes academic literature from the Web of Science Core Collection (1999–2024). VOSviewer was used to assess countries/regions, institutions, and co-cited journals for clustering and timeline visualizations. CiteSpace was employed to examine authors, co-cited authors, journals, references, and keywords for clustering, timeline visualizations, and burst detection. Additionally, Biblioshiny was used to create a global collaboration map of countries/regions.</p> Results <p>This global analysis included 4,863 articles from 132 countries/regions, over 5,700 institutions, and 26,931 authors. Recent years show a significant increase in publication volume. The study mapped the global distribution and identified key contributing countries, authors, and institutions. Current research hotspots focus on ARGs and immunotherapy. The findings highlight the need to address host-related factors, lifecycle-specific issues, regional research disparities, and antibiotic resistance pressures. Novel therapeutic approaches and their integration with environmental science require further exploration to advance resistance management.</p> Conclusion <p>This study is the first to use a systematic review to explore trends and emerging hotspots in antibiotic resistance and gut microbiota research. The identification of key contributors, including leading countries, institutions, authors, and journals, providing a foundation for advancing further collaboration and progress. It also highlights underexplored areas and potential future directions through a bibliometric perspective.</p>

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Mapping 25 years of research on gut microbiota and antibiotic resistance: bibliometric insights and future directions

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Yiwei Heng,
  • Mengping Wang,
  • Zhen Zhang,
  • Enlin Jian,
  • Chenchen Wu,
  • Chengwei Zhang,
  • Qing Chen,
  • Xiaoping Yu,
  • Yanfeng Zhu,
  • Peiling Cai

摘要

Objective

Antibiotic resistance poses a major global public health threat. It compromises human health and increases healthcare burdens. The gut microbiota serves as a critical reservoir for antibiotic resistance genes (ARGs). It plays a pivotal role in the spread and evolution of antibiotic resistance. This study systematically analyzes the literature regarding on antibiotic resistance and gut microbiota from 1999 to 2024. It aims to elucidate global distribution, collaboration patterns, key contributors, current research hotspots, and future directions.

Methods

This study analyzes academic literature from the Web of Science Core Collection (1999–2024). VOSviewer was used to assess countries/regions, institutions, and co-cited journals for clustering and timeline visualizations. CiteSpace was employed to examine authors, co-cited authors, journals, references, and keywords for clustering, timeline visualizations, and burst detection. Additionally, Biblioshiny was used to create a global collaboration map of countries/regions.

Results

This global analysis included 4,863 articles from 132 countries/regions, over 5,700 institutions, and 26,931 authors. Recent years show a significant increase in publication volume. The study mapped the global distribution and identified key contributing countries, authors, and institutions. Current research hotspots focus on ARGs and immunotherapy. The findings highlight the need to address host-related factors, lifecycle-specific issues, regional research disparities, and antibiotic resistance pressures. Novel therapeutic approaches and their integration with environmental science require further exploration to advance resistance management.

Conclusion

This study is the first to use a systematic review to explore trends and emerging hotspots in antibiotic resistance and gut microbiota research. The identification of key contributors, including leading countries, institutions, authors, and journals, providing a foundation for advancing further collaboration and progress. It also highlights underexplored areas and potential future directions through a bibliometric perspective.