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<p>We describe an unusual cross-transmission of carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) in an intensive care unit, initially mediated by a contaminated gastroscope and subsequently through environmental dissemination. A first patient acquired OXA-23/NDM-producing CRAB after gastroscopy, with a fatal outcome. A second patient, admitted to the same room, became colonized without endoscopic exposure. Whole-genome sequencing confirmed a clonal strain (ST570) among patients and environmental samples. This transmission underscores the critical need for rigorous endoscope reprocessing, environmental decontamination, and surveillance of emerging transmission routes to prevent nosocomial infections.</p>

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An unusual cross-transmission of carbapenem-resistant Acinetobacter baumannii: when the endoscope isn’t the only culprit

  • 期刊论文

  • 发表日期：

    2026年1月24日

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  • Guillaume Mellon,
  • Céline Ciotti,
  • Hadrien Kimseng,
  • Aymeric Braille,
  • Véronique Bourdais,
  • Nathalie Osinski,
  • Bénédicte Condamine,
  • Béatrice Berçot,
  • Maïté Chaussard,
  • Lucie Guillemet,
  • Gabriel Marcellier,
  • Emmanuel Dudoignon,
  • François Caméléna,
  • Delphine Seytre

摘要

We describe an unusual cross-transmission of carbapenem-resistant Acinetobacter baumannii (CRAB) in an intensive care unit, initially mediated by a contaminated gastroscope and subsequently through environmental dissemination. A first patient acquired OXA-23/NDM-producing CRAB after gastroscopy, with a fatal outcome. A second patient, admitted to the same room, became colonized without endoscopic exposure. Whole-genome sequencing confirmed a clonal strain (ST570) among patients and environmental samples. This transmission underscores the critical need for rigorous endoscope reprocessing, environmental decontamination, and surveillance of emerging transmission routes to prevent nosocomial infections.