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Purpose <p><i>Candida auris</i> is an emerging multidrug-resistant fungal pathogen known for its ability to cause healthcare-associated outbreaks. Although only sporadic cases have been reported in Belgium, increasing incidence in Europe highlights the need for early detection strategies. This study aimed to evaluate <i>C. auris</i> colonisation among high-risk patients and assess three detection methods.</p> Methods <p>A total of 100 patients were screened using two eSwabs® per patient from: (i) axillae and groins, and (ii) nose, throat and perineum. Culture on CHROMagar Candida plus was compared with two molecular assays: Altostar<sup>®</sup> Candida auris PCR, and AurisID. Given the overlap in risk factors for <i>C. auris</i> and other multi-drug resistant organisms, the feasibility of culturing <i>C. auris</i> from an enrichment broth containing TSB and 2.5% sodium chloride, often used for MRSA enrichment, was evaluated.</p> Results <p>Analytical evaluation showed high specificity of the molecular assays with no cross-reactivity to clinically relevant non-target yeasts. Culture on CHROMagar Candida plus appeared more sensitive than both molecular methods. No <i>C. auris</i> carriage was detected among all screened patients.</p> Conclusion <p><i>Candida auris</i> was not detected in the screened population, indicating a very low or absent prevalence at present. However, surveillance is essential to ensure early recognition and address the risk of future spread.</p>

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Prospective surveillance of Candida auris and assessment of diagnostic approaches in a Belgian hospital

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Kim Callebaut,
  • Jorn Hellemans,
  • Taeyang Chin,
  • Katelijne Floré,
  • Merijn Vanhee,
  • Sylvia Snauwaert,
  • Alexander Schauwvlieghe,
  • Bram Dewulf,
  • Marijke Reynders,
  • Astrid Muyldermans

摘要

Purpose

Candida auris is an emerging multidrug-resistant fungal pathogen known for its ability to cause healthcare-associated outbreaks. Although only sporadic cases have been reported in Belgium, increasing incidence in Europe highlights the need for early detection strategies. This study aimed to evaluate C. auris colonisation among high-risk patients and assess three detection methods.

Methods

A total of 100 patients were screened using two eSwabs® per patient from: (i) axillae and groins, and (ii) nose, throat and perineum. Culture on CHROMagar Candida plus was compared with two molecular assays: Altostar® Candida auris PCR, and AurisID. Given the overlap in risk factors for C. auris and other multi-drug resistant organisms, the feasibility of culturing C. auris from an enrichment broth containing TSB and 2.5% sodium chloride, often used for MRSA enrichment, was evaluated.

Results

Analytical evaluation showed high specificity of the molecular assays with no cross-reactivity to clinically relevant non-target yeasts. Culture on CHROMagar Candida plus appeared more sensitive than both molecular methods. No C. auris carriage was detected among all screened patients.

Conclusion

Candida auris was not detected in the screened population, indicating a very low or absent prevalence at present. However, surveillance is essential to ensure early recognition and address the risk of future spread.