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<p><i>Saprochaete species</i> are emerging fungal pathogens, particularly affecting immunocompromised individuals, with clinical manifestations ranging from superficial to invasive infections. We present three cases of pediatric <i>Saprochaete spp.</i> infections, detailing clinical presentation, diagnostic workup, and treatment strategies. Two patients with acute myeloid leukemia developed bloodstream infections with <i>Saprochaete clavata</i>; both required prolonged antifungal therapy due to deep organ involvement, and one experienced relapse after treatment discontinuation. The third case involved a patient with cystic fibrosis, in whom <i>Saprochaete capitata</i> was isolated from sputum; she improved with antifungal therapy and had no relapse. <i>Saprochaete spp.</i> infections in pediatric populations present diagnostic and therapeutic challenges. Further research is needed to optimize management strategies and improve patient outcomes.</p>

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Pediatric saprochaete infections: insights from case reports

  • 期刊论文

  • 发表日期：

    2025年12月12日

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  • Sevgi Aslan Tuncay,
  • Gulsen Akkoc,
  • Zeynep Ergenc,
  • Seyhan Yılmaz,
  • Burcu Parlak,
  • Aylin Dizi Isik,
  • Pinar Canizci Erdemli,
  • Didem Buyuktas Aytac,
  • Meryem Cagla Abaci Capar,
  • Rabia Emel Senay,
  • Burcu Tufan Tas,
  • Nursah Eker,
  • Ahmet Koc,
  • Eda Kepenekli,
  • Sevliya Ocal Demir

摘要

Saprochaete species are emerging fungal pathogens, particularly affecting immunocompromised individuals, with clinical manifestations ranging from superficial to invasive infections. We present three cases of pediatric Saprochaete spp. infections, detailing clinical presentation, diagnostic workup, and treatment strategies. Two patients with acute myeloid leukemia developed bloodstream infections with Saprochaete clavata; both required prolonged antifungal therapy due to deep organ involvement, and one experienced relapse after treatment discontinuation. The third case involved a patient with cystic fibrosis, in whom Saprochaete capitata was isolated from sputum; she improved with antifungal therapy and had no relapse. Saprochaete spp. infections in pediatric populations present diagnostic and therapeutic challenges. Further research is needed to optimize management strategies and improve patient outcomes.