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<p>Mobile colistin resistance (<i>mcr</i>) genes, initially described in livestock and humans, remain less frequently reported in companion animals. We conducted a global genomic survey of 14,643 bacterial genomes retrieved from the NCBI National Database of Antibiotic Resistant Organisms and identified 105 (0.7%) <i>mcr</i>-positive <i>Enterobacterales</i> from dogs (79.0%) and cats (21.0%). <i>Escherichia coli</i> (73.3%) and the <i>Enterobacter cloacae</i> complex (20.9%) predominated, with the <i>mcr-1</i> and <i>mcr-9</i> variants being the most frequent. Most genomes originated from Asia, Europe, and North America, reflecting the uneven geographic distribution of sequenced <i>mcr</i>-positive strains. Genomic analysis revealed a genetic plurality and co-occurrence of <i>mcr</i> genes with CTX-M-type extended-spectrum β-lactamases (46.6%), carbapenemases (5.7%), and 16S rRNA methyltransferases (8.6%), particularly in international high-risk clones. These findings underscore the diversity and epidemiological relevance of <i>mcr</i>-positive bacteria in pets, reinforcing the need for closer monitoring through One Health-based surveillance.</p>

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Global genomic characteristics of mobile colistin resistance mcr genes in Enterobacterales from companion animals

  • 期刊论文

  • 发表日期：

    2025年12月2日

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  • João Pedro Rueda Furlan,
  • Che Song,
  • Xinyue Zhai,
  • Qian Tong,
  • Eliana Guedes Stehling,
  • Nilton Lincopan,
  • Zhi Ruan,
  • Fábio Parra Sellera

摘要

Mobile colistin resistance (mcr) genes, initially described in livestock and humans, remain less frequently reported in companion animals. We conducted a global genomic survey of 14,643 bacterial genomes retrieved from the NCBI National Database of Antibiotic Resistant Organisms and identified 105 (0.7%) mcr-positive Enterobacterales from dogs (79.0%) and cats (21.0%). Escherichia coli (73.3%) and the Enterobacter cloacae complex (20.9%) predominated, with the mcr-1 and mcr-9 variants being the most frequent. Most genomes originated from Asia, Europe, and North America, reflecting the uneven geographic distribution of sequenced mcr-positive strains. Genomic analysis revealed a genetic plurality and co-occurrence of mcr genes with CTX-M-type extended-spectrum β-lactamases (46.6%), carbapenemases (5.7%), and 16S rRNA methyltransferases (8.6%), particularly in international high-risk clones. These findings underscore the diversity and epidemiological relevance of mcr-positive bacteria in pets, reinforcing the need for closer monitoring through One Health-based surveillance.