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<p>The human-oral associated <i>Capnocytophaga</i> species are low-grade pathogens, more commonly affecting immunocompromised patients. Bloodstream infections are the most common clinical presentation. Microbiological diagnosis and antibiotic susceptibility testing are challenging due to the hard-to-growth character of these species, which complicates the initiation of effective antibiotic therapy. We present the case of an immunocompromised 60-year-old female receiving cefepime who developed febrile neutropenia. Blood cultures remained positive for a <i>Capnocytophaga gingivalis</i> isolate producing the CSP-1 extended-spectrum-β-lactamase (ESBL). This is the first description of CSP-1 in a non-<i>C. sputigena</i> species. Immune reconstitution led to clinical resolution. </p>

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Invasive CSP-1-Capnocytophaga gingivalis in a 60 year-old female with severe neutropenia

  • 期刊论文

  • 发表日期：

    2025年10月22日

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  • Malo Penven,
  • Hugo Leroyer-Gravet,
  • Aminata Cisse,
  • Maxime Lecourt,
  • Tony Marchand,
  • Vincent Cattoir

摘要

The human-oral associated Capnocytophaga species are low-grade pathogens, more commonly affecting immunocompromised patients. Bloodstream infections are the most common clinical presentation. Microbiological diagnosis and antibiotic susceptibility testing are challenging due to the hard-to-growth character of these species, which complicates the initiation of effective antibiotic therapy. We present the case of an immunocompromised 60-year-old female receiving cefepime who developed febrile neutropenia. Blood cultures remained positive for a Capnocytophaga gingivalis isolate producing the CSP-1 extended-spectrum-β-lactamase (ESBL). This is the first description of CSP-1 in a non-C. sputigena species. Immune reconstitution led to clinical resolution.