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<p>A 52-year-old man with a 30-year history of chronic alcohol abuse presented withseizures and progressive cognitive decline. Brain MRI demonstrated symmetricdiffusion-weighted hyperintensities involving the genu, body, and splenium of thecorpus callosum, extending to the anterior commissure, with corresponding restricteddiffusion on the apparent diffusion coefficient map. These findings were consistent withMarchiafava–Bignami disease, reflecting a toxic–metabolic demyelinating processassociated with chronic alcohol exposure.</p>

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Anterior commissure involvement in Marchiafava–Bignami disease: MRI findings

  • 期刊论文

  • 发表日期：

    2026年5月25日

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  • Ying Chen,
  • Yin Lu,
  • Jie Chen

摘要

A 52-year-old man with a 30-year history of chronic alcohol abuse presented withseizures and progressive cognitive decline. Brain MRI demonstrated symmetricdiffusion-weighted hyperintensities involving the genu, body, and splenium of thecorpus callosum, extending to the anterior commissure, with corresponding restricteddiffusion on the apparent diffusion coefficient map. These findings were consistent withMarchiafava–Bignami disease, reflecting a toxic–metabolic demyelinating processassociated with chronic alcohol exposure.