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<p>Autoimmune cerebellar ataxia (ACA) is a complex neurological disorder characterized by immune-mediated damage to the cerebellum, which gives rise to ataxia symptom. Auto-neuronal antibodies play a crucial role in the diagnosis of ACA. We present a case of an early 70s male whose main presenting symptom was subacute cerebellar ataxia. Enhanced cranial magnetic resonance imaging (MRI) did not detect any significant cerebellar lesions. The serum anti-neurochondroitin (NCDN) antibody IgG titer was 1:320, while the cerebrospinal fluid anti-NCDN antibody IgG titer was 1:1. After the administration of intravenous immunoglobulin (IVIG) and glucocorticoids, the patient’s symptoms were rapidly relieved. During a six-month follow-up period, the patient’s condition did not recur and it was maintained with low-dose oral glucocorticoids. Threrfore, It is recommended that auto-neurologic antibody testing be included into the routine diagnostic process for patients suspected of having ACA to enable early diagnosis. Early initiation of immunotherapy may significantly improve the prognosis of ACA patients.</p>

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A case of autoimmune cerebellar ataxia associated with anti-neurochondroitin antibody

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Jing Yang,
  • Yixuan Xu,
  • Ying Huang

摘要

Autoimmune cerebellar ataxia (ACA) is a complex neurological disorder characterized by immune-mediated damage to the cerebellum, which gives rise to ataxia symptom. Auto-neuronal antibodies play a crucial role in the diagnosis of ACA. We present a case of an early 70s male whose main presenting symptom was subacute cerebellar ataxia. Enhanced cranial magnetic resonance imaging (MRI) did not detect any significant cerebellar lesions. The serum anti-neurochondroitin (NCDN) antibody IgG titer was 1:320, while the cerebrospinal fluid anti-NCDN antibody IgG titer was 1:1. After the administration of intravenous immunoglobulin (IVIG) and glucocorticoids, the patient’s symptoms were rapidly relieved. During a six-month follow-up period, the patient’s condition did not recur and it was maintained with low-dose oral glucocorticoids. Threrfore, It is recommended that auto-neurologic antibody testing be included into the routine diagnostic process for patients suspected of having ACA to enable early diagnosis. Early initiation of immunotherapy may significantly improve the prognosis of ACA patients.