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<p>Acute isolated peripheral facial nerve palsy is mainly idiopathic. In a minority of cases, however, it may result from other disorders that complicate the diagnostic process. Atypical clinical features, temporal evolution, and associated signs or symptoms are crucial in guiding diagnostic suspicion. In this case, we discuss a 57-year-old woman with acute unilateral facial weakness. The clinical course, together with the combination of imaging and laboratory studies, ultimately led to the final diagnosis of neurosiphilis. In the antibiotic era, the number of patients with the classic form of neurosphilis has decreased, while the frequency of subtle and atypical forms has increased so that neurosyphilis may occur without prior evidence or manifestation of infection [<CitationRef AdditionalCitationIDS="CR2" CitationID="CR1">1</CitationRef>–<CitationRef CitationID="CR3">3</CitationRef>]. When one or more cranial nerves are affected in the absence of meningeal signs or fever, the diagnosis can be particularly challenging given the wide range of differential diagnoses of cranial multineuropathies [<CitationRef CitationID="CR4">4</CitationRef>]. This case emphasizes the role of clinical reasoning in addressing atypical presentations of common neurological syndromes.</p>

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Bell’s palsy as the first manifestation of neurosyphilis in an immunocompetent and HIV-negative patient: a challenging diagnosis

  • 期刊论文

  • 发表日期：

    2026年3月23日

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  • Marco Bisquoli,
  • Massimo Bondavalli,
  • Claudia Lazzaretti,
  • Manuela Napoli,
  • Letizia Caprari,
  • Pedro Fraiman,
  • Sergio Mezzadri,
  • Sara Montepietra,
  • Francesco Cavallieri

摘要

Acute isolated peripheral facial nerve palsy is mainly idiopathic. In a minority of cases, however, it may result from other disorders that complicate the diagnostic process. Atypical clinical features, temporal evolution, and associated signs or symptoms are crucial in guiding diagnostic suspicion. In this case, we discuss a 57-year-old woman with acute unilateral facial weakness. The clinical course, together with the combination of imaging and laboratory studies, ultimately led to the final diagnosis of neurosiphilis. In the antibiotic era, the number of patients with the classic form of neurosphilis has decreased, while the frequency of subtle and atypical forms has increased so that neurosyphilis may occur without prior evidence or manifestation of infection [1–3]. When one or more cranial nerves are affected in the absence of meningeal signs or fever, the diagnosis can be particularly challenging given the wide range of differential diagnoses of cranial multineuropathies [4]. This case emphasizes the role of clinical reasoning in addressing atypical presentations of common neurological syndromes.