Scholarlink

Introduction <p>Tuberculous meningitis (TBM) is a devastating form of extrapulmonary tuberculosis with high mortality and substantial long-term neurological sequelae. Cognitive impairment is a particularly debilitating outcome yet remains under-recognised and understudied. However, heterogeneous methodologies and tools remain a major barrier to pooling data and forming clinical guidelines.</p> Aims and objectives <p>To evaluate the prevalence, patterns, and determinants of cognitive impairment among adult TBM patients.</p> Methodology <p>A total of 761 records were identified, and six studies met the inclusion criteria and were included in the qualitative synthesis, of which four studies were included in the quantitative meta-analysis.</p> Results <p>Cognitive impairment ranging from 12% to over 90% was found across studies, with severity ranging from mild deficits to severe global dysfunction. The most consistently affected domains were memory, attention, and executive function, followed by language and visuospatial.</p> Conclusion <p>Multidomain cognitive impairment is a common sequela of tuberculous meningitis, underscoring the need for routine screening and long-term rehabilitation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Unmasking the cognitive burden of adult tuberculous meningitis: A systematic review and meta analysis

  • 期刊论文

  • 发表日期：

    2026年2月3日

查看全文
  • Sanchit Shailendra Chouksey,
  • Akansha Jain,
  • Varun Kumar Singh,
  • Rameshwar Nath Chaurasia,
  • Abhishek Pathak,
  • Shahnawaz Ahmad,
  • Pranjal Kumar Singh,
  • Deepika Joshi,
  • Vijay Nath Mishra,
  • Anand Kumar

摘要

Introduction

Tuberculous meningitis (TBM) is a devastating form of extrapulmonary tuberculosis with high mortality and substantial long-term neurological sequelae. Cognitive impairment is a particularly debilitating outcome yet remains under-recognised and understudied. However, heterogeneous methodologies and tools remain a major barrier to pooling data and forming clinical guidelines.

Aims and objectives

To evaluate the prevalence, patterns, and determinants of cognitive impairment among adult TBM patients.

Methodology

A total of 761 records were identified, and six studies met the inclusion criteria and were included in the qualitative synthesis, of which four studies were included in the quantitative meta-analysis.

Results

Cognitive impairment ranging from 12% to over 90% was found across studies, with severity ranging from mild deficits to severe global dysfunction. The most consistently affected domains were memory, attention, and executive function, followed by language and visuospatial.

Conclusion

Multidomain cognitive impairment is a common sequela of tuberculous meningitis, underscoring the need for routine screening and long-term rehabilitation.