Scholarlink

Objective <p>Epidemiological studies have suggested that single nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene may contribute to the etiology of multiple sclerosis (MS). However, the results to date have been inconsistent, even contradictory.</p> Methods <p>A meta-analysis was conducted to investigate the potential association between IL-10 SNPs and MS susceptibility. Five English-language databases (PubMed, Embase, Web of Science, CNKI, and Wanfang) were searched for relevant studies. Crude odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the relationship between IL-10–1082&#xa0;A &gt; G (rs1800896), -819T &gt; C (rs1800871), -592&#xa0;A &gt; C (rs1800872) polymorphisms, their haplotypes, and MS susceptibility. Publication bias, sensitivity analyses, and cumulative analyses were performed to evaluate the robustness and reliability of the findings.</p> Results <p>Fourteen articles (30 independent case-control studies) were included, revealing significant associations between the − 1082&#xa0;A &gt; G polymorphism and MS susceptibility in the general population (G vs. A: OR = 1.14, 95%CI = 1.05–1.24, <i>P</i> = 0.002, I<sup>2</sup> = 18.6%; AG vs. AA: OR = 1.32, 95%CI = 1.15–1.52, <i>P</i> &lt; 0.001, I<sup>2</sup> = 36.1%; GG vs. AA: OR = 1.30, 95%CI = 1.10–1.55, <i>P</i> = 0.003, I<sup>2</sup> = 25.0%; AG + GG vs. AA: OR = 1.31, 95%CI = 1.15–1.49, <i>P</i> &lt; 0.001, I<sup>2</sup> = 35.8%) and several subgroup models. Furthermore, the mutant GCC haplotype also exhibited a significant risk on MS susceptibility.</p> Conclusion <p>In summary, this current meta-analysis suggested that the IL-10 gene polymorphisms may be the substantial factors for the development of MS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between interleukin-10 gene polymorphisms and multiple sclerosis susceptibility: evidence from a meta-analysis

  • 期刊论文

  • 发表日期：

    2026年1月21日

查看全文
  • Yue-Long Xu,
  • Yu-Ming Niu

摘要

Objective

Epidemiological studies have suggested that single nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene may contribute to the etiology of multiple sclerosis (MS). However, the results to date have been inconsistent, even contradictory.

Methods

A meta-analysis was conducted to investigate the potential association between IL-10 SNPs and MS susceptibility. Five English-language databases (PubMed, Embase, Web of Science, CNKI, and Wanfang) were searched for relevant studies. Crude odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the relationship between IL-10–1082 A > G (rs1800896), -819T > C (rs1800871), -592 A > C (rs1800872) polymorphisms, their haplotypes, and MS susceptibility. Publication bias, sensitivity analyses, and cumulative analyses were performed to evaluate the robustness and reliability of the findings.

Results

Fourteen articles (30 independent case-control studies) were included, revealing significant associations between the − 1082 A > G polymorphism and MS susceptibility in the general population (G vs. A: OR = 1.14, 95%CI = 1.05–1.24, P = 0.002, I2 = 18.6%; AG vs. AA: OR = 1.32, 95%CI = 1.15–1.52, P < 0.001, I2 = 36.1%; GG vs. AA: OR = 1.30, 95%CI = 1.10–1.55, P = 0.003, I2 = 25.0%; AG + GG vs. AA: OR = 1.31, 95%CI = 1.15–1.49, P < 0.001, I2 = 35.8%) and several subgroup models. Furthermore, the mutant GCC haplotype also exhibited a significant risk on MS susceptibility.

Conclusion

In summary, this current meta-analysis suggested that the IL-10 gene polymorphisms may be the substantial factors for the development of MS.