Scholarlink

Background <p>Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system with a multifactorial aetiology, including vitamin D levels, that have been linked to disease activity. Given the inconsistent findings on the vitamin D supplementation in MS, we aimed to analyse the connection between 25(OH)D levels and disease activity and to identify an optimal level of 25(OH)D in MS utilizing our real-world database.</p> Methods <p>This study utilized a 10-year dataset from the Czech national multiple sclerosis registry (ReMuS), encompassing 1,861 adult MS patients. Patients had a minimum of one year of follow-up, with subgroup analysis for those with at least five years. A mixed-effects model tested the impact of 25(OH)D and cholesterol levels on relapse incidence. Subgroup analysis categorised patients by average 25(OH)D levels and analysed relapse incidence using the Kruskal-Wallis test and Kaplan-Meier survival analysis.</p> Results <p>Higher serum 25(OH)D levels and age correlated with reduced relapse risk (<i>p</i> &lt; 0.001 for both). Each 10 nmol/L increase in 25(OH)D levels associated with a 6.7% decrease in relapse risk (<i>p</i> &lt; 0.001). Cholesterol levels and sex did not significantly affect relapse rate. Subgroup analysis revealed that patients with 25(OH)D levels above 100 nmol/L had significantly fewer relapses compared to those with levels below 75 nmol/L.</p> Conclusion <p>Our findings suggest that optimising 25(OH)D levels may reduce the risk of relapse in pwMS. Causation cannot be confirmed. Results highlight the importance of personalized vitamin D supplementation strategies and support the potential benefit of maintaining optimal serum 25(OH)D levels in MS management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

From sunlight to MS fight: impact of vitamin D levels on multiple sclerosis activity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月23日

查看全文
  • Marta Vachova,
  • Dominika Stastna,
  • Aneta Mazouchova,
  • Pavla Hruskova,
  • Tomas Uher,
  • Jana Preiningerova Lizrova,
  • Pavel Potuznik,
  • Jiri Drahota,
  • Eva Kubala Havrdova

摘要

Background

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system with a multifactorial aetiology, including vitamin D levels, that have been linked to disease activity. Given the inconsistent findings on the vitamin D supplementation in MS, we aimed to analyse the connection between 25(OH)D levels and disease activity and to identify an optimal level of 25(OH)D in MS utilizing our real-world database.

Methods

This study utilized a 10-year dataset from the Czech national multiple sclerosis registry (ReMuS), encompassing 1,861 adult MS patients. Patients had a minimum of one year of follow-up, with subgroup analysis for those with at least five years. A mixed-effects model tested the impact of 25(OH)D and cholesterol levels on relapse incidence. Subgroup analysis categorised patients by average 25(OH)D levels and analysed relapse incidence using the Kruskal-Wallis test and Kaplan-Meier survival analysis.

Results

Higher serum 25(OH)D levels and age correlated with reduced relapse risk (p < 0.001 for both). Each 10 nmol/L increase in 25(OH)D levels associated with a 6.7% decrease in relapse risk (p < 0.001). Cholesterol levels and sex did not significantly affect relapse rate. Subgroup analysis revealed that patients with 25(OH)D levels above 100 nmol/L had significantly fewer relapses compared to those with levels below 75 nmol/L.

Conclusion

Our findings suggest that optimising 25(OH)D levels may reduce the risk of relapse in pwMS. Causation cannot be confirmed. Results highlight the importance of personalized vitamin D supplementation strategies and support the potential benefit of maintaining optimal serum 25(OH)D levels in MS management.