Scholarlink

Background <p>Sleep disturbance (SD) is a common non-motor symptom of Parkinson’s disease (PD), and autonomic dysfunction is believed to play a key role in its worsening. However, the independent contribution of each autonomic domain to SD remains unclear. We aimed to investigate the influence of autonomic dysfunction on SD in drug-naïve patients with PD.</p> Methods <p>We conducted a cross-sectional study of 89 drug-naïve patients with PD. SD was assessed using the PD Sleep Scale-version-2 (PDSS-2) and Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire. Autonomic symptoms were evaluated using the Scale for Outcomes in PD-Autonomic Dysfunction (SCOPA-AUT). Multiple regression analyses were performed to identify the autonomic domains contributing to the PDSS-2 after adjusting for age, sex, disease duration, motor severity, frontal executive function, depression, and visual illusion.</p> Results <p>In the multivariable analyses, SCOPA-AUT gastrointestinal (β = 0.252, <i>P</i> = 0.018), urinary (β = 0.296, <i>P</i> = 0.004), cardiovascular (β = 0.230, <i>P</i> = 0.024), and thermoregulatory domains (β = 0.240, <i>P</i> = 0.019), along with depression, were independently associated with high PDSS-2 scores. The pupillomotor and sexual domains were not significantly associated with SD. In addition, a decline in blood pressure during the head-up tilt test was associated with high PDSS-2 scores.</p> Conclusion <p>Multiple autonomic domains may contribute to SD in drug-naïve patients with PD. Early identification and management of autonomic dysfunction could improve sleep quality and overall quality of life in this population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Influence of autonomic dysfunction on sleep disturbance in drug-naïve patients with Parkinson’s disease

  • 期刊论文

  • 发表日期：

    2025年12月22日

查看全文
  • Masakazu Ozawa,
  • Hidetomo Murakami,
  • Hirotaka James Okano,
  • Yutaka Matsushita,
  • Shu Fujimoto,
  • Yuichiro Muraoka,
  • Momoyo Ibukuro,
  • Masahiro Mimori,
  • Yuki Asahara,
  • Hiromasa Matsuno,
  • Tadashi Umehara,
  • Shusaku Omoto,
  • Renpei Sengoku,
  • Yasuyuki Iguchi

摘要

Background

Sleep disturbance (SD) is a common non-motor symptom of Parkinson’s disease (PD), and autonomic dysfunction is believed to play a key role in its worsening. However, the independent contribution of each autonomic domain to SD remains unclear. We aimed to investigate the influence of autonomic dysfunction on SD in drug-naïve patients with PD.

Methods

We conducted a cross-sectional study of 89 drug-naïve patients with PD. SD was assessed using the PD Sleep Scale-version-2 (PDSS-2) and Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire. Autonomic symptoms were evaluated using the Scale for Outcomes in PD-Autonomic Dysfunction (SCOPA-AUT). Multiple regression analyses were performed to identify the autonomic domains contributing to the PDSS-2 after adjusting for age, sex, disease duration, motor severity, frontal executive function, depression, and visual illusion.

Results

In the multivariable analyses, SCOPA-AUT gastrointestinal (β = 0.252, P = 0.018), urinary (β = 0.296, P = 0.004), cardiovascular (β = 0.230, P = 0.024), and thermoregulatory domains (β = 0.240, P = 0.019), along with depression, were independently associated with high PDSS-2 scores. The pupillomotor and sexual domains were not significantly associated with SD. In addition, a decline in blood pressure during the head-up tilt test was associated with high PDSS-2 scores.

Conclusion

Multiple autonomic domains may contribute to SD in drug-naïve patients with PD. Early identification and management of autonomic dysfunction could improve sleep quality and overall quality of life in this population.