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Purpose <p>To assess the safety and effectiveness of tACS as a therapeutic intervention for older adults with cognitive impairment.</p> Materials and methods <p>From the time of library construction until March 3, 2025, we conducted a comprehensive search of the databases PubMed, Embase, Web of Science and Cochrane Library. Additionally, we manually examined the references in the articles. The outcome indicators were cognitive function, which included memory function, attention, overall cognition, as well as safety.</p> Results <p>6 publications with a total of 888 subjects were included. The tACS group did better at treating cognitive impairment, especially memory problems (SMD = 0.7, 95% Cl = 0.29 to 1.12, I2 = 52%, P = 0.0009) and overall cognition (SMD = 1.97, 95% Cl = -0.87 to 3.06, I2 = 0%, P = 0.0004). However, it did not have good efficacy on attention. Furthermore, tACS was a very safe treatment.</p> Conclusions <p>tACS is very effective in the treatment of older adults with cognitive impairment, especially for memory function and overall cognition. In addition, tACS is a very safe treatment. However, in the future, there is still a need for many high-quality clinical studies on tACS for cognitive impairment.</p>

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Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年1月9日

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  • Shenhong Ma,
  • Qiaohua Han,
  • Di Zhang,
  • Heling Wang,
  • Weisheng Zhuang,
  • Wanyue Li,
  • Ying Li,
  • Beibei Lei,
  • Yage Wang

摘要

Purpose

To assess the safety and effectiveness of tACS as a therapeutic intervention for older adults with cognitive impairment.

Materials and methods

From the time of library construction until March 3, 2025, we conducted a comprehensive search of the databases PubMed, Embase, Web of Science and Cochrane Library. Additionally, we manually examined the references in the articles. The outcome indicators were cognitive function, which included memory function, attention, overall cognition, as well as safety.

Results

6 publications with a total of 888 subjects were included. The tACS group did better at treating cognitive impairment, especially memory problems (SMD = 0.7, 95% Cl = 0.29 to 1.12, I2 = 52%, P = 0.0009) and overall cognition (SMD = 1.97, 95% Cl = -0.87 to 3.06, I2 = 0%, P = 0.0004). However, it did not have good efficacy on attention. Furthermore, tACS was a very safe treatment.

Conclusions

tACS is very effective in the treatment of older adults with cognitive impairment, especially for memory function and overall cognition. In addition, tACS is a very safe treatment. However, in the future, there is still a need for many high-quality clinical studies on tACS for cognitive impairment.