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Background <p>The hepatic steatosis index (HSI) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD), a condition that can increase the risk of atherosclerosis. However, limited data are available on the association between HSI and asymptomatic intracranial arterial stenosis (aICAS).</p> Methods <p>This cross-sectional study aimed to investigate the association between HSI and aICAS among Chinese rural residents. The study enrolled 1788 participants aged ≥ 40 years without a history of clinical stroke or transient ischemic attack from the Rose Asymptomatic Intracranial Artery Stenosis (RICAS) cohort. We defined aICAS as ≥ 50% stenosis in intracranial arteries confirmed through combined transcranial Doppler (TCD) ultrasound and magnetic resonance angiography (MRA). The HSI was calculated based on gender, diabetes, body mass index (BMI), and transaminases level. The multivariate logistic regression models were deployed to explore the association of HSI with aICAS.</p> Results <p>Of the 1788 participants, the participants with aICAS comparing with those without aICAS had a significantly higher HSI. Controlling for confounding factors, HSI ≥ 36 was significantly associated with aICAS (OR = 3.08; 95%CI: 1.46–6.49, <i>P</i> = 0.003), especially multiple aICAS (OR = 4.21; 95%CI: 1.31–13.47, <i>P</i> = 0.016). The prevalence of aICAS increased with the value of HSI (<i>P</i> for trend = 0.001). Subgroup analysis further showed the association between HSI and aICAS risk only in non-abdominally obese populations (<i>P</i> for interaction = 0.023).</p> Conclusions <p>HSI may serve as a practical non-invasive biomarker for aICAS risk stratification, thus facilitating early detection in community settings, particularly in non-abdominally obese populations.</p>

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Association of hepatic steatosis index with asymptomatic intracranial arterial stenosis: a cross-sectional study

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Xu Han,
  • Yongli Pan,
  • Jiao Li,
  • Peiyao Liu,
  • Ruichun Jin,
  • Yuanyuan Zhao,
  • Xiaotong Ma,
  • Xiang Wang,
  • Peng Yan,
  • Qinjian Sun

摘要

Background

The hepatic steatosis index (HSI) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD), a condition that can increase the risk of atherosclerosis. However, limited data are available on the association between HSI and asymptomatic intracranial arterial stenosis (aICAS).

Methods

This cross-sectional study aimed to investigate the association between HSI and aICAS among Chinese rural residents. The study enrolled 1788 participants aged ≥ 40 years without a history of clinical stroke or transient ischemic attack from the Rose Asymptomatic Intracranial Artery Stenosis (RICAS) cohort. We defined aICAS as ≥ 50% stenosis in intracranial arteries confirmed through combined transcranial Doppler (TCD) ultrasound and magnetic resonance angiography (MRA). The HSI was calculated based on gender, diabetes, body mass index (BMI), and transaminases level. The multivariate logistic regression models were deployed to explore the association of HSI with aICAS.

Results

Of the 1788 participants, the participants with aICAS comparing with those without aICAS had a significantly higher HSI. Controlling for confounding factors, HSI ≥ 36 was significantly associated with aICAS (OR = 3.08; 95%CI: 1.46–6.49, P = 0.003), especially multiple aICAS (OR = 4.21; 95%CI: 1.31–13.47, P = 0.016). The prevalence of aICAS increased with the value of HSI (P for trend = 0.001). Subgroup analysis further showed the association between HSI and aICAS risk only in non-abdominally obese populations (P for interaction = 0.023).

Conclusions

HSI may serve as a practical non-invasive biomarker for aICAS risk stratification, thus facilitating early detection in community settings, particularly in non-abdominally obese populations.