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Background <p>This study aimed at delineating the temporal trends of epilepsy among women of childbearing age (WCBA), offering essential insights for prevention and management approaches in specific population.</p> Methods <p>Data from the Global Burden of Disease (GBD) 2021 were used to measure the burden of epilepsy among WCBA by region, country, age, and sociodemographic index (SDI). Age-period-cohort model, joinpoint regression analysis and the Auto Regressive Integrated Moving Average (ARIMA) model were carried out.</p> Results <p>The global prevalence, years-lived with disability (YLDs) rates of idiopathic epilepsy among WCBA show a decrease in 2021 compared with 1992, while the global prevalence and YLDs rates of secondary epilepsy increased; notably, the absolute number of cases has continued to rise. Low, low-middle and middle SDI regions face a growing epilepsy burden compared with higher SDI regions while high-SDI regions also showed higher idiopathic epilepsy prevalence among WCBA. The age effect revealed a general decline in idiopathic and total epilepsy prevalence with increasing age across global and SDI regions, in contrast to a progressive rise in secondary epilepsy prevalence. Unfavorable period effects of idiopathic and secondary epilepsy among WCBA were mostly exhibited in low, low-middle, middle and high SDI region. Favorable birth cohort effects were always seen in high-middle SDI region.</p> Conclusions <p>This study elucidates the complex epidemiological landscape of epilepsy among WCBA, noting a increase in disease burden. Strengthening epilepsy health education, optimizing WCBA epilepsy diagnosis and treatment and emphasizing WCBA epilepsy prevention can effectively reduce new cases of epilepsy and related disabilities.</p>

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Global temporal trends and projections of epilepsy in women of childbearing age: insights from the global burden of disease study 2021

  • 期刊论文

  • 发表日期：

    2025年10月9日

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  • Siyuan Yang,
  • Xiaoyu Ji,
  • Dejing Cheng,
  • Chengyuan Ji

摘要

Background

This study aimed at delineating the temporal trends of epilepsy among women of childbearing age (WCBA), offering essential insights for prevention and management approaches in specific population.

Methods

Data from the Global Burden of Disease (GBD) 2021 were used to measure the burden of epilepsy among WCBA by region, country, age, and sociodemographic index (SDI). Age-period-cohort model, joinpoint regression analysis and the Auto Regressive Integrated Moving Average (ARIMA) model were carried out.

Results

The global prevalence, years-lived with disability (YLDs) rates of idiopathic epilepsy among WCBA show a decrease in 2021 compared with 1992, while the global prevalence and YLDs rates of secondary epilepsy increased; notably, the absolute number of cases has continued to rise. Low, low-middle and middle SDI regions face a growing epilepsy burden compared with higher SDI regions while high-SDI regions also showed higher idiopathic epilepsy prevalence among WCBA. The age effect revealed a general decline in idiopathic and total epilepsy prevalence with increasing age across global and SDI regions, in contrast to a progressive rise in secondary epilepsy prevalence. Unfavorable period effects of idiopathic and secondary epilepsy among WCBA were mostly exhibited in low, low-middle, middle and high SDI region. Favorable birth cohort effects were always seen in high-middle SDI region.

Conclusions

This study elucidates the complex epidemiological landscape of epilepsy among WCBA, noting a increase in disease burden. Strengthening epilepsy health education, optimizing WCBA epilepsy diagnosis and treatment and emphasizing WCBA epilepsy prevention can effectively reduce new cases of epilepsy and related disabilities.