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<p>Aim of this study is to assess the effects of subthalamic deep brain stimulation (STN-DBS) on cardiovascular and sudomotor autonomic functions in Parkinson’s disease (PD) patients. Ten subjects with advanced PD and bilateral STN-DBS underwent head-up tilt test (HUTT) and electrochemical skin conductance (ESC) measured with Sudoscan, under three conditions: DBS ON and therapy OFF (DBS ON/Th OFF), 30&#xa0;min after switching off the DBS (DBS OFF/Th OFF), and 30&#xa0;min after switching on the DBS and administering melevodopa/carbidopa 100/25&#xa0;mg (DBS ON/Th ON). A significant reduction in systolic blood pressure at the 10th minute of HUTT in the DBS ON/Th ON condition was detected, compared to the DBS OFF/Th OFF condition (p 0.036). No other significant differences were observed in heart rate (HR), blood pressure (BP) and electro-chemical skin conductance among the three conditions. STN-DBS does not influence cardiovascular and sudomotor autonomic regulation, however, it may exert a positive effect on cardiovascular reactivity by an indirect mechanism, as it decreases levodopa load.</p>

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Subthalamic deep brain stimulation does not impact on cardiovascular and sudomotor functions assessed by head-up tilt test and sudoscan

  • 期刊论文

  • 发表日期：

    2025年9月26日

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  • Camilla Rocchi,
  • Kristi Meksi,
  • Rocco Cerroni,
  • Elena Garasto,
  • Francesco Bove,
  • Carla Piano,
  • Nicola Biagio Mercuri,
  • Alessandro Stefani,
  • Livia Brusa

摘要

Aim of this study is to assess the effects of subthalamic deep brain stimulation (STN-DBS) on cardiovascular and sudomotor autonomic functions in Parkinson’s disease (PD) patients. Ten subjects with advanced PD and bilateral STN-DBS underwent head-up tilt test (HUTT) and electrochemical skin conductance (ESC) measured with Sudoscan, under three conditions: DBS ON and therapy OFF (DBS ON/Th OFF), 30 min after switching off the DBS (DBS OFF/Th OFF), and 30 min after switching on the DBS and administering melevodopa/carbidopa 100/25 mg (DBS ON/Th ON). A significant reduction in systolic blood pressure at the 10th minute of HUTT in the DBS ON/Th ON condition was detected, compared to the DBS OFF/Th OFF condition (p 0.036). No other significant differences were observed in heart rate (HR), blood pressure (BP) and electro-chemical skin conductance among the three conditions. STN-DBS does not influence cardiovascular and sudomotor autonomic regulation, however, it may exert a positive effect on cardiovascular reactivity by an indirect mechanism, as it decreases levodopa load.