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<p>The incidence of Neurodegenerative Diseases is on the rise, paralleling the societal trend of an aging population and the extension of the average life expectancy. NDs frequently manifest varying levels of chronic fatigue, a phenomenon whose underlying mechanisms remain obscure. This condition significantly impairs the quality of life for patients and presents a formidable challenge to our nation’s healthcare system. This paper delves into the potential mechanisms, assessments, and therapeutic approaches for Parkinson’s Disease and Multiple System Atrophy in the context of chronic fatigue. The objective of this study is to enhance the understanding of chronic fatigue in NDs, as well as to contribute to the advancement of its diagnosis and treatment methodologies.</p>

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Research progress of chronic fatigue in neurodegenerative diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月10日

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  • Luxuan Xia,
  • Liye Wang,
  • Wenyang Tian,
  • Qianyu Zhao,
  • Xinning Zhang,
  • Shenghua Kang,
  • Yao Wang,
  • Xiaoxue Li,
  • Wenxuan Guo,
  • Jingmei Zhao,
  • Yuanxin Zhang,
  • Zhigang Chen,
  • Nannan Li

摘要

The incidence of Neurodegenerative Diseases is on the rise, paralleling the societal trend of an aging population and the extension of the average life expectancy. NDs frequently manifest varying levels of chronic fatigue, a phenomenon whose underlying mechanisms remain obscure. This condition significantly impairs the quality of life for patients and presents a formidable challenge to our nation’s healthcare system. This paper delves into the potential mechanisms, assessments, and therapeutic approaches for Parkinson’s Disease and Multiple System Atrophy in the context of chronic fatigue. The objective of this study is to enhance the understanding of chronic fatigue in NDs, as well as to contribute to the advancement of its diagnosis and treatment methodologies.